Overview of Genetically Determined Diseases/Multiple Endocrine Neoplasia Syndromes Predisposing to Endocrine Tumors

Abel Decmann, A. Patócs, P. Igaz

Research output: Review article

1 Citation (Scopus)

Abstract

In this chapter, we present an overview of multiple endocrine neoplasia syndromes including their most important clinical and molecular features. Multiple endocrine neoplasia type 1 and 2 syndromes (MEN1 and MEN2) are discussed in detail. Syndromes that are presented in other chapters are only briefly mentioned. We discuss the relevance of germline gene alterations in apparently sporadic endocrine tumors, e.g., medullary thyroid cancer, primary hyperparathyroidism, and neuroendocrine tumors. McCune-Albright syndrome that only exists in non-hereditary, sporadic forms is also discussed in detail, as tumors of several endocrine organs can develop in the same individual.

Original languageEnglish
Pages (from-to)105-127
Number of pages23
JournalExperientia supplementum (2012)
Volume111
DOIs
Publication statusPublished - jan. 1 2019

ASJC Scopus subject areas

  • Medicine(all)

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