Oversulfated mucopolysaccharides in the otosclerotic bone

Ottó Ribári, Maxim Pereplica, István Sziklai

Research output: Article

11 Citations (Scopus)


Mucopolysaccharides (glucosaminoglycans, GAGs) were extracted from otosclerotic and non-otosclerotic human stapes footplate, stapes superstructure and guinea pig stapes footplate. Cellulose acetate electrophoresis revealed an unknown highly anionic band (Rf=1.05) beside the conventional hyaluronic acid, chondroitin sulfate and heparan sulfate fractions. Chemical analysis resulted in a high sulfate/hexosamine molar ratio in the otosclerotic GAG extract (1.7 and 1.9) and a very low ratio in non-otosclerotic human stapes and normal guinea pig stapes footplate GAG extract (0.20 and 0.21, respectively). Hex-uronic acid content was highest in guinea pig stapes GAG preparation. Our results serve as indirect evidence of the presence of an oversulfated GAG fraction in the otosclerotic bone, which can potentially initiate otosclerotic bone resorption.

Original languageEnglish
Pages (from-to)362-365
Number of pages4
JournalActa Oto-Laryngologica
Issue number2
Publication statusPublished - jan. 1 1991

ASJC Scopus subject areas

  • Otorhinolaryngology

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