Hormonális fogamzásgátlás, gesztációs események és a Leiden-mutáció elofordulása mélyvénás thrombosis miatt kezelt betegek között

Research output: Article


The authors studied the frequency of oral contraceptive use and the presence of Leiden-mutation among women of fertile age treated for deep vein thrombosis. They found 76 female patients less than 45 years of age at the time of diagnosis of their deep vein thromboses. A structured self-administered questionnaire was completed and returned by 50 patients including data of their contraceptive history, obstetric events and predisposing factors. Molecular biology tests were performed in 45 cases in order to identify Leiden-mutation. 40% of the patients were on combined contraceptive pills and 12% were pregnant or delivered recently at the time of the deep vein thrombosis. The presence of Leiden-mutation was confirmed in a heterozygous form in 34% of the patients. 8% of the cases were homozygous for the Leiden-mutation. 58% of the deep vein thrombosis patients were on the pill, were pregnant or had a childbirth recently, and had the Leiden-mutation at the time of the diagnosis. With such a high frequency of Leiden-mutation in the studied population, one may propose that routine screening for APC-resistance is recommended in countries with similarly high allelic frequency.

Original languageHungarian
Pages (from-to)191-195
Number of pages5
JournalMagyar Noorvosok Lapja
Issue number3
Publication statusPublished - jan. 1 2001



  • Leiden-mutation
  • Oral contraception
  • Thrombosis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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