Optimization of triacetylfusarinine C and ferricrocin productions in Aspergillus fumigatus

Zsuzsa M. Szigeti, Szilvia Szaniszló, Erika Fazekas, G. Gyémánt, Judit Szabon, K. Antal, T. Emri, J. Balla, G. Balla, L. Csernoch, I. Pócsi

Research output: Article

7 Citations (Scopus)

Abstract

Iron is an essential element for all microorganisms. Bacteria and fungi produce versatile siderophores for binding and storing this essential transition metal when its availability is limited in the environment. The aim of the study was to optimize the fermentation medium of Aspergillus fumigatus for siderophore production. Triacetyl-fusarinine C and ferricrocin yields were dependent on glucose and glycine supplementations as well as the initial pH of the culture media. The optimal fermentation medium for triacetylfusarinine C production contained 8% glucose, 0.4% glycine and the initial pH was set to 5.9. Meanwhile, maximal ferricrocin yields were recorded in the presence of 10% glucose, 0.5% glycine and at an initial pH of 7.4. Under optimized fermentation conditions, the yields for triacetylfusarinine C and ferricrocin increased up to 2.9 g/l culture medium and 18.9 mg/g mycelium, respectively.

Original languageEnglish
Pages (from-to)107-119
Number of pages13
JournalActa Microbiologica et Immunologica Hungarica
Volume61
Issue number2
DOIs
Publication statusPublished - jún. 1 2014

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Aspergillus fumigatus
Glycine
Fermentation
Siderophores
Glucose
Culture Media
Mycelium
Fungi
Iron
Metals
Bacteria
N,N',N''-triacetylfusarinine C
ferricrocin

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

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title = "Optimization of triacetylfusarinine C and ferricrocin productions in Aspergillus fumigatus",
abstract = "Iron is an essential element for all microorganisms. Bacteria and fungi produce versatile siderophores for binding and storing this essential transition metal when its availability is limited in the environment. The aim of the study was to optimize the fermentation medium of Aspergillus fumigatus for siderophore production. Triacetyl-fusarinine C and ferricrocin yields were dependent on glucose and glycine supplementations as well as the initial pH of the culture media. The optimal fermentation medium for triacetylfusarinine C production contained 8{\%} glucose, 0.4{\%} glycine and the initial pH was set to 5.9. Meanwhile, maximal ferricrocin yields were recorded in the presence of 10{\%} glucose, 0.5{\%} glycine and at an initial pH of 7.4. Under optimized fermentation conditions, the yields for triacetylfusarinine C and ferricrocin increased up to 2.9 g/l culture medium and 18.9 mg/g mycelium, respectively.",
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T1 - Optimization of triacetylfusarinine C and ferricrocin productions in Aspergillus fumigatus

AU - Szigeti, Zsuzsa M.

AU - Szaniszló, Szilvia

AU - Fazekas, Erika

AU - Gyémánt, G.

AU - Szabon, Judit

AU - Antal, K.

AU - Emri, T.

AU - Balla, J.

AU - Balla, G.

AU - Csernoch, L.

AU - Pócsi, I.

PY - 2014/6/1

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N2 - Iron is an essential element for all microorganisms. Bacteria and fungi produce versatile siderophores for binding and storing this essential transition metal when its availability is limited in the environment. The aim of the study was to optimize the fermentation medium of Aspergillus fumigatus for siderophore production. Triacetyl-fusarinine C and ferricrocin yields were dependent on glucose and glycine supplementations as well as the initial pH of the culture media. The optimal fermentation medium for triacetylfusarinine C production contained 8% glucose, 0.4% glycine and the initial pH was set to 5.9. Meanwhile, maximal ferricrocin yields were recorded in the presence of 10% glucose, 0.5% glycine and at an initial pH of 7.4. Under optimized fermentation conditions, the yields for triacetylfusarinine C and ferricrocin increased up to 2.9 g/l culture medium and 18.9 mg/g mycelium, respectively.

AB - Iron is an essential element for all microorganisms. Bacteria and fungi produce versatile siderophores for binding and storing this essential transition metal when its availability is limited in the environment. The aim of the study was to optimize the fermentation medium of Aspergillus fumigatus for siderophore production. Triacetyl-fusarinine C and ferricrocin yields were dependent on glucose and glycine supplementations as well as the initial pH of the culture media. The optimal fermentation medium for triacetylfusarinine C production contained 8% glucose, 0.4% glycine and the initial pH was set to 5.9. Meanwhile, maximal ferricrocin yields were recorded in the presence of 10% glucose, 0.5% glycine and at an initial pH of 7.4. Under optimized fermentation conditions, the yields for triacetylfusarinine C and ferricrocin increased up to 2.9 g/l culture medium and 18.9 mg/g mycelium, respectively.

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KW - triacetylfusarinine C

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