Optimization of impulsive discrete-time tumor chemotherapy

Daniel Andras Drexler, Levente Kovacs

Research output: Conference contribution

1 Citation (Scopus)

Abstract

Cancer therapies, like chemotherapy are generally based on heuristic approaches and expert knowledge. Introducing mathematical and engineering methods into the therapy design process has great potentials in therapy optimization. We investigate the application of a discrete time, impulsive therapy generation algorithm for a model that describes living tumor and dead tumor volume dynamics, drug level dynamics, using mixed-order pharmacokinetics and input saturation. We propose an algorithm that calculates low doses of injections that are required to reach or approximate the best results that can be achieved by the application of the drug. The algorithm is tested based on virtual patients (mice) whose parameters are identified based on measurement from experiments with pegylated liposomal doxorubicin as cytotoxic agent and breast cancer as tumor. The algorithm tested in silico shows much better performance than the protocol used in the experiments.

Original languageEnglish
Title of host publication2019 1st International Conference on Societal Automation, SA 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728133454
DOIs
Publication statusPublished - szept. 2019
Event1st International Conference on Societal Automation, SA 2019 - Krakow, Poland
Duration: szept. 4 2019szept. 6 2019

Publication series

Name2019 1st International Conference on Societal Automation, SA 2019

Conference

Conference1st International Conference on Societal Automation, SA 2019
CountryPoland
CityKrakow
Period9/4/199/6/19

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ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Networks and Communications
  • Computer Science Applications
  • Decision Sciences (miscellaneous)
  • Control and Optimization

Cite this

Drexler, D. A., & Kovacs, L. (2019). Optimization of impulsive discrete-time tumor chemotherapy. In 2019 1st International Conference on Societal Automation, SA 2019 [8938056] (2019 1st International Conference on Societal Automation, SA 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SA47457.2019.8938056