Opiate mechanism in reward-related neuronal responses during operant feeding behavior of the monkey

Yutaka Oomura, Hitoo Nishino, Shuji Aou, László Lénárd

Research output: Article

30 Citations (Scopus)


Reward-related neuronal activity and its modulation by morphine and naloxone was investigated by extracellular single neuron recording and electrophoretic application of drugs in the lateral hypothalamus, during operant feeding of the monkey. Morphine-sensitive neurons responded more often during bar press and ingestion-reward phase. Naloxone blocked only ingestion-reward responses, especially the inhibitory ones. The results suggest that the central opiate system can be involved in reward-related neuronal responses in the lateral hypothalamic area of the monkey.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalBrain research
Issue number2
Publication statusPublished - febr. 19 1986


ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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