Obţinerea şi caracterizarea fizico-chimicǎ a compuşilor de incluziune ai unui diuretic sulfonamidic cu β-ciclodextrinǎ metilatǎ

Codruţa Şoica, Árpád Gyéresi, Zoltan Aigner, Mihaly Kata, Cristina Dehelean

Research output: Article

4 Citations (Scopus)

Abstract

Furosemide is a practically insoluble in water sulphonamidic diuretic, used for the treatment of edema and hypertension. Randomly-methylated-β- cyclodextrin(RAMEB) was used as a host molecule to improve its solubility in water, via inclusion complex formation. Different molar ratios (1:1, 1:2) and various preparation methods (physical mixing, kneading, ultrasonication) were used in order to obtain the inclusion complexes. Phase solubility diagram of furosemide and RAMEB was constructed and a diagram of AL type was obtained, with a stability constant of 130 M-1. The inclusion complexes were analysed by in vitro dissolution tests, differential scanning calorimetry and X-ray diffraction. As water solubility increased, the partition coefficients of the products decreased.

Original languageRomanian
Pages (from-to)392-397
Number of pages6
JournalRevista de Chimie
Volume57
Issue number4
Publication statusPublished - ápr. 2006

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ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science (miscellaneous)
  • Engineering(all)
  • Surfaces, Coatings and Films
  • Materials Chemistry

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