Nucleoside 5'-phosphordiamidates

S. Boitka, J. Tomasz

Research output: Article

8 Citations (Scopus)


A one-flask method is reported for the preparation of the 5'-phosphordiamidate of adenosine (3a), cytidine (3b), guanosine (3c), uridine (3d) and thymidine (3e), and also for that of adenosine 5'-(N,N'-dimethyl) phosphordiamidate (4a), adenosine 5'-(N,N,N',N'-tetramethyl) phosphordiamidate (5a) and adenosine 5'-phosphor-dimorpholidate (6a). The method is based on the aminolysis of nucleoside 5'-phosphordichloridates performed in situ by NH4OH, or aqueous amine solutions, respectively.

Original languageEnglish
Pages (from-to)2909-2912
Number of pages4
Issue number24
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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