Novel neuroprotective strategies in ischemic retinal lesions

Krisztina Szabadfi, Laszlo Mester, Dora Reglodi, Peter Kiss, Norbert Babai, Boglarka Racz, Krisztina Kovacs, Aliz Szabo, Aliz Tamas, Robert Gabriel, Tamas Atlasz

Research output: Review article

25 Citations (Scopus)

Abstract

Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K + channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.

Original languageEnglish
Pages (from-to)544-561
Number of pages18
JournalInternational journal of molecular sciences
Volume11
Issue number2
DOIs
Publication statusPublished - febr. 1 2010

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ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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