Novel β-lactam condensed 3-thiaquinolines: an efficient synthesis and structural characterization

Péter Csomós, Lajos Fodor, Gábor Bernáth, Jari Sinkkonen, Jari Salminen, Kirsti Wiinamäki, Kalevi Pihlaja

Research output: Article

30 Citations (Scopus)

Abstract

Quinoline analog 2-aryl-4H-3,1-benzothiazine derivatives 8-13, obtained by the condensation of o-aminobenzyl chloride 1 with substituted thiobenzamides 2-7, were transformed to azeto[2,1-a][3,1]benzothiazin-1-one derivatives 18-23a,b,c and 24d,e by reaction with the corresponding substituted acetyl chlorides 14-17 in the presence of triethylamine. The structures of the new molecules were determined by NMR spectroscopy and electron ionization (EI) mass spectrometry. The typical EI+ mass spectrometric fragmentations of 8-13 and 18-23a,b,c and 24d,e are discussed in detail.

Original languageEnglish
Pages (from-to)1002-1011
Number of pages10
JournalTetrahedron
Volume64
Issue number6
DOIs
Publication statusPublished - febr. 4 2008

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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