Non-adenosine nucleoside inosine, guanosine and uridine as promising antiepileptic drugs: A summary of current literature

Z. Kovács, K. Kékesi, G. Juhász, János Barna, László Héja, Renáta Lakatos, A. Dobolyi

Research output: Article

14 Citations (Scopus)

Abstract

Adenosine (Ado) and some non-adenosine (non-Ado) nucleosides including inosine (Ino), guanosine (Guo) and uridine (Urd) are modulatory molecules in the central nervous system (CNS), regulating different physiological and pathophysiological processes in the brain such as sleep and epilepsy. Indeed, different drugs effective on adenosinergic system (e.g., Ado metabolism inhibitors, agonists and antagonists of Ado receptors) are being used in drug development for the treatment of epileptic disorders. Although (i) endogenous Ino, Guo and Urd showed anticonvulsant/antiepileptic effects (e.g., in quinolinic acid - induced seizures and in different epilepsy models such as hippocampal kindling models), and (ii) there is a need to generate new and more effective antiepileptic drugs for the treatment of drug-resistant epilepsies, our knowledge about antiepileptic influence of non-Ado nucleosides is far from complete. Thus, in this review article, we give a short summary of anticonvulsant/antiepileptic effects and mechanisms evoked by Ino, Guo, and Urd. Finally, we discuss some non-Ado nucleoside derivatives and their structures, which may be candidates as potential antiepileptic agents.

Original languageEnglish
Pages (from-to)1033-1042
Number of pages10
JournalMini-Reviews in Medicinal Chemistry
Volume14
Issue number13
Publication statusPublished - okt. 1 2014

Fingerprint

Inosine
Guanosine
Uridine
Nucleosides
Anticonvulsants
Adenosine
Epilepsy
Purinergic P1 Receptor Agonists
Physiological Phenomena
Purinergic P1 Receptor Antagonists
Quinolinic Acid
Pharmaceutical Preparations
Sleep
Seizures
Central Nervous System
Brain
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Medicine(all)

Cite this

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abstract = "Adenosine (Ado) and some non-adenosine (non-Ado) nucleosides including inosine (Ino), guanosine (Guo) and uridine (Urd) are modulatory molecules in the central nervous system (CNS), regulating different physiological and pathophysiological processes in the brain such as sleep and epilepsy. Indeed, different drugs effective on adenosinergic system (e.g., Ado metabolism inhibitors, agonists and antagonists of Ado receptors) are being used in drug development for the treatment of epileptic disorders. Although (i) endogenous Ino, Guo and Urd showed anticonvulsant/antiepileptic effects (e.g., in quinolinic acid - induced seizures and in different epilepsy models such as hippocampal kindling models), and (ii) there is a need to generate new and more effective antiepileptic drugs for the treatment of drug-resistant epilepsies, our knowledge about antiepileptic influence of non-Ado nucleosides is far from complete. Thus, in this review article, we give a short summary of anticonvulsant/antiepileptic effects and mechanisms evoked by Ino, Guo, and Urd. Finally, we discuss some non-Ado nucleoside derivatives and their structures, which may be candidates as potential antiepileptic agents.",
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T2 - A summary of current literature

AU - Kovács, Z.

AU - Kékesi, K.

AU - Juhász, G.

AU - Barna, János

AU - Héja, László

AU - Lakatos, Renáta

AU - Dobolyi, A.

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