Nicorandil suppressed ventricular arrhythmias in a canine model of myocardial ischaemia

A. Végh, Kati Györgyi, J. Papp, Kazushige Sakai, J. Parratt

Research output: Article

20 Citations (Scopus)

Abstract

These experiments were designed to explore the possibility that a K+ channel opener which also donates nitric oxide to the myocardium (nicorandil) may modify ischaemia-induced ventricular arrhythmias in a large animal model. In mongrel dogs anaesthetised with chloralose-urethane and thoracotomised, a side branch of the left anterior descending artery was catheterised for the local intracoronary infusion of nicorandil (2.5 μg kg-1 min-1 for 20 min prior to coronary artery occlusion and then continuing throughout the 25 min occlusion period). In this dose, nicorandil had no haemodynamic effects, increased coronary blood flow by up to 16% and significantly reduced the severity of ischaemia-induced arrhythmias (e.g. from nearly 500 ventricular premature beats in the controls to 160 ± 60 in the nicorandil group). There was a significant reduction in the number of episodes of ventricular tachycardia during the ischaemic period and a reduced incidence of ventricular fibrillation following reperfusion resulting in a 42% survival from the combined ischaemia-reperfusion insult (cf. 0% in the control; P <0.05). The marked changes that occurred in ST-segment elevation (mapped with epicardial electrodes) and in the inhomogeneity of electrical activation within the ischaemic area in control dogs was markedly reduced in those dogs administered nicorandil. We conclude that the local intracoronary administration of nicorandil reduces the severity of both ischaemia and the life-threatening arrhythmias that result from an abrupt reduction in coronary blood flow in this canine model. Possible mechanisms include an increase in coronary blood flow, a reduction in the severity of myocardial ischaemia and an ability of the compound to 'donate' nitric oxide to the ischaemic area.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalEuropean Journal of Pharmacology
Volume305
Issue number1-3
DOIs
Publication statusPublished - jún. 3 1996

Fingerprint

Nicorandil
Myocardial Ischemia
Canidae
Cardiac Arrhythmias
Ischemia
Dogs
Reperfusion
Nitric Oxide
Chloralose
Ventricular Premature Complexes
Coronary Occlusion
Urethane
Ventricular Fibrillation
Ventricular Tachycardia
Coronary Vessels
Myocardium
Electrodes
Animal Models
Arteries
Hemodynamics

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Nicorandil suppressed ventricular arrhythmias in a canine model of myocardial ischaemia. / Végh, A.; Györgyi, Kati; Papp, J.; Sakai, Kazushige; Parratt, J.

In: European Journal of Pharmacology, Vol. 305, No. 1-3, 03.06.1996, p. 163-168.

Research output: Article

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abstract = "These experiments were designed to explore the possibility that a K+ channel opener which also donates nitric oxide to the myocardium (nicorandil) may modify ischaemia-induced ventricular arrhythmias in a large animal model. In mongrel dogs anaesthetised with chloralose-urethane and thoracotomised, a side branch of the left anterior descending artery was catheterised for the local intracoronary infusion of nicorandil (2.5 μg kg-1 min-1 for 20 min prior to coronary artery occlusion and then continuing throughout the 25 min occlusion period). In this dose, nicorandil had no haemodynamic effects, increased coronary blood flow by up to 16{\%} and significantly reduced the severity of ischaemia-induced arrhythmias (e.g. from nearly 500 ventricular premature beats in the controls to 160 ± 60 in the nicorandil group). There was a significant reduction in the number of episodes of ventricular tachycardia during the ischaemic period and a reduced incidence of ventricular fibrillation following reperfusion resulting in a 42{\%} survival from the combined ischaemia-reperfusion insult (cf. 0{\%} in the control; P <0.05). The marked changes that occurred in ST-segment elevation (mapped with epicardial electrodes) and in the inhomogeneity of electrical activation within the ischaemic area in control dogs was markedly reduced in those dogs administered nicorandil. We conclude that the local intracoronary administration of nicorandil reduces the severity of both ischaemia and the life-threatening arrhythmias that result from an abrupt reduction in coronary blood flow in this canine model. Possible mechanisms include an increase in coronary blood flow, a reduction in the severity of myocardial ischaemia and an ability of the compound to 'donate' nitric oxide to the ischaemic area.",
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