Several bifunctional nitrosoureido sugar alcohol derivatives were synthesized at the Institute for Drug Research in Budapest. For detailed studies two D,L-threitol derivatives have been selected (GYK1 13 324, GYKI 13485). These compounds were less toxic and more effective than BCNU, the calculated therapeutic index values in a broad scale of transplantable, induced and heterotransplanted tumours were found to be more advantageous than with the referent compound. Both GYKI 13324 and GYKI 13485 exert their curative effect when given orally even in leukaemia types of tumours. Their effect on the blood picture of rats is moderate and of short duration.
ASJC Scopus subject areas
- Cancer Research