Új perspektíva a krónikus mieloid leukémia kezelésében? Géncsendesítéses terápia

Kiss Tóth Éva, Juhászné Szalai Adrienn, Koska Péter, Szebeni János, Kiss Tóth Emöke, Barkai László, Fodor Bertalan

Research output: Article

1 Citation (Scopus)

Abstract

Chronic myeloid leukemia is an incurable white blood cell disease with slow progression which affects myeloid stem cells. In the course of chromosome 22 shortening a fusion oncogene arises whose product, a Bcr-Abl oncoprotein, is a continuously expressed tyrosine kinase protein. Beside the opportunity of chemotherapy, stem cell therapy and interferon-A therapy, the application of tyrosine kinase inhibitors also became widespread in the treatment of the disease. Patients bearing the T315I point mutation, however, show resistance against all tyrosine kinase inhibitors, which can be managed by dose escalation or the combination of therapies. The discovery of RNA interference or gene silencing put the therapeutic opportunity of CML in new light. The in vitro application of anti-bcr-abl siRNA showed promising results in the causal treatment of the disease, feasible for identification of new genes associated to the disease, but we do not have sufficient evidence for the safety and efficacy of this method in human therapy.

Translated title of the contributionNew perspective in the treatment of chronic myeloid leukemia? Gene silencing therapy
Original languageHungarian
Pages (from-to)16-22
Number of pages7
JournalMagyar onkologia
Volume56
Issue number1
Publication statusPublished - 2012

Keywords

  • Chronic myeloid leukemia
  • Fusion oncogene
  • Gene silencing
  • SiRNA
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Medicine(all)

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    Éva, K. T., Adrienn, J. S., Péter, K., János, S., Emöke, K. T., László, B., & Bertalan, F. (2012). Új perspektíva a krónikus mieloid leukémia kezelésében? Géncsendesítéses terápia. Magyar onkologia, 56(1), 16-22.