New-onset Diabetes Mellitus Following Successful Kidney Transplantation Facilitates Aortic Stiffening

Bernadett Borda, György Lázár, Árpád Kormányos, Péter Domsik, Anita Kalapos, Edit Szederkényi, Csaba Lengyel, Tamás Várkonyi, Csilla Keresztes, Tamás Forster, Attila Nemes

Research output: Article

1 Citation (Scopus)


Background: Following kidney transplantation (KT), new-onset diabetes mellitus (NODM) is one of the most common complications. NODM usually occurs early after KT, and is diagnosed according to the general guidelines relevant for general diabetes mellitus patients. Arterial stiffness is a surrogate marker of cardiovascular risk. According to the literature, a successful KT has only limited and late beneficial effects on aortic elastic properties. The present study aimed to assess whether NODM has any additive value on the worsening of echocardiography-derived aortic elastic properties in transplanted patients. Methods: We have included 28 nondiabetic post-KT patients in the study, older than 18 years (mean age: 48.2 ± 6.9 years; 13 men, 15 women). After an oral glucose tolerance test, 8 patients were diagnosed with NODM, and their results were compared to 23 age-, sex-, and risk factor-matched controls (mean age: 54.9 ± 11.0 years; 9 men, 14 women). All post-KT patients and matched controls underwent a complete transthoracic 2-dimensional Doppler echocardiography, together with an assessment of echocardiographic aortic elastic properties. The assessments included aortic strain, aortic distensibility, and aortic stiffness index. Results: Aortic elastic properties showed alterations in post-KT patients compared to matched controls (aortic strain: .084 ± .039 vs .057 ± .032, P < .05; aortic distensibility: 2.36 ± 1.09 cm2/dynes 10–6 vs 1.83 ± 1.18 cm2/dynes 10–6, P = .07; aortic stiffness index: 7.15 ± 3.58 vs 11.2 ± 6.1, P < .05). Further deterioration in the aortic stiffness index (14.8 ± 7.6 vs 9.68 ± 4.88, P < .05) was detected in the presence of NODM. Conclusions: NODM following successful KT facilitates aortic stiffening.

Original languageEnglish
Pages (from-to)1239-1243
Number of pages5
JournalTransplantation proceedings
Issue number4
Publication statusPublished - máj. 2019

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Fingerprint Dive into the research topics of 'New-onset Diabetes Mellitus Following Successful Kidney Transplantation Facilitates Aortic Stiffening'. Together they form a unique fingerprint.

  • Cite this