New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum

S. Nyiredy, Zs Samu, Z. Szücs, K. Gulácsi, T. Kurtán, S. Antus

Research output: Article

17 Citations (Scopus)

Abstract

It has been demonstrated that besides the known flavanolignan constituents of the white-flowered variant of Silybum marianum, (-)-silandrin A (3a) and (-)-isosilandrin A (4a); their transbenzodioxane diastereomers, (-)-silandrin B (3b) and (-)-isosilandrin B (4b), are also produced by the plant. Moreover, the isolation of their cis-benzodioxane diastereomers, (-)-isocisilandrin (5) and cisilandrin (6), confirm that the previously proposed biosynthetic pathway involving a nonselective O-β coupling is correct.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalJournal of Chromatographic Science
Volume46
Issue number2
Publication statusPublished - febr. 2008

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Milk Thistle
Biosynthesis
Biosynthetic Pathways
3-deoxysilybin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

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abstract = "It has been demonstrated that besides the known flavanolignan constituents of the white-flowered variant of Silybum marianum, (-)-silandrin A (3a) and (-)-isosilandrin A (4a); their transbenzodioxane diastereomers, (-)-silandrin B (3b) and (-)-isosilandrin B (4b), are also produced by the plant. Moreover, the isolation of their cis-benzodioxane diastereomers, (-)-isocisilandrin (5) and cisilandrin (6), confirm that the previously proposed biosynthetic pathway involving a nonselective O-β coupling is correct.",
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T1 - New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum

AU - Nyiredy, S.

AU - Samu, Zs

AU - Szücs, Z.

AU - Gulácsi, K.

AU - Kurtán, T.

AU - Antus, S.

PY - 2008/2

Y1 - 2008/2

N2 - It has been demonstrated that besides the known flavanolignan constituents of the white-flowered variant of Silybum marianum, (-)-silandrin A (3a) and (-)-isosilandrin A (4a); their transbenzodioxane diastereomers, (-)-silandrin B (3b) and (-)-isosilandrin B (4b), are also produced by the plant. Moreover, the isolation of their cis-benzodioxane diastereomers, (-)-isocisilandrin (5) and cisilandrin (6), confirm that the previously proposed biosynthetic pathway involving a nonselective O-β coupling is correct.

AB - It has been demonstrated that besides the known flavanolignan constituents of the white-flowered variant of Silybum marianum, (-)-silandrin A (3a) and (-)-isosilandrin A (4a); their transbenzodioxane diastereomers, (-)-silandrin B (3b) and (-)-isosilandrin B (4b), are also produced by the plant. Moreover, the isolation of their cis-benzodioxane diastereomers, (-)-isocisilandrin (5) and cisilandrin (6), confirm that the previously proposed biosynthetic pathway involving a nonselective O-β coupling is correct.

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