New carbohydrate derivatives of norfloxacin

Virág Zsoldos-Mády, P. Sohár, J. Kovács, I. Pintér, Zoltán Szakács

Research output: Article

3 Citations (Scopus)

Abstract

New classes of sugar derivatives of the antibacterial drug norfloxacin (1) were synthesized by substituting the N-4′ of the piperazinyl moiety of the molecule. Direct coupling with gluco- and galactopyranosyl units afforded glycosylamines 2-5. Introduction of urea or thiourea linkage between glycosyl and norfloxacin units was produced with the corresponding glycosyl isocyanates or isothiocyanates. For the synthesis of unprotected sugar urea compounds, a new approach was applied by using 1,2-N, O-carbonyl-β-D-glycopyranoses. Hydrazinocarbonyl-methyl- and -propyl spacers also were found appropriate for linking norfloxacin with sugar units.

Original languageEnglish
Pages (from-to)19-39
Number of pages21
JournalJournal of Carbohydrate Chemistry
Volume24
Issue number1
DOIs
Publication statusPublished - 2005

Fingerprint

Norfloxacin
Sugars
Carbohydrates
Derivatives
Urea
Isothiocyanates
Isocyanates
Thiourea
Molecules
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

New carbohydrate derivatives of norfloxacin. / Zsoldos-Mády, Virág; Sohár, P.; Kovács, J.; Pintér, I.; Szakács, Zoltán.

In: Journal of Carbohydrate Chemistry, Vol. 24, No. 1, 2005, p. 19-39.

Research output: Article

Zsoldos-Mády, Virág ; Sohár, P. ; Kovács, J. ; Pintér, I. ; Szakács, Zoltán. / New carbohydrate derivatives of norfloxacin. In: Journal of Carbohydrate Chemistry. 2005 ; Vol. 24, No. 1. pp. 19-39.
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