Neutral-Red Uptake by Amniotic-Fluid Macrophages in Neural-Tube Defects: A Rapid Test

Katalin Pulgár, Sándor Sipka, György Abel, Zoltán Papp

Research output: Letter

5 Citations (Scopus)


To the Editor: Determination of alpha-fetoprotein and acetylcholinesterase levels and ultrasonic methods have been used in the diagnosis of fetal neural-tube defects. In addition, macrophages are present in cultures of amniotic-fluid samples obtained from cases of fetal neural-tube defects.1 These macrophages appear as rapidly adhering cells in culture vessels within 12 to 24 hours after cultivation. Other workers have determined the prevalence of these cells and their morphologic properties instead of enumerating macrophage populations.2 3 4 More recently, direct microscopical examination of cytologic smears, instead of culture techniques, has been developed as a method of diagnosis.5 6 7 We report on a simple method.

Original languageEnglish
Pages (from-to)1463-1464
Number of pages2
JournalNew England Journal of Medicine
Issue number22
Publication statusPublished - máj. 31 1984

ASJC Scopus subject areas

  • Medicine(all)

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