Neurofibromatosis, melanoma malignum és hyperthyreosis egy HCV-pozitív betegen

Anikó Folhoffer, Andrea Horváth, Tímea Csák, László Nébenführer, Márta Telkes, András Iványi, Ferenc Szalay

Research output: Article


INTRODUCTION - Similar occirrence of neurofibromatosis and malignant melanoma is rare. We report a patient with neurofibromatosis, cutaneous melanoma, hyperthyreoidism and HCV positivity. CASE REPORT - A 43-year-old woman has been under care for neurofibromatosis for 16 years when she presented with increased serum ?-glutamyltransferase, alkaline phosphatase activity and anti-HCV antibody positivity at regular check-up. A pigmented lesion removed from her back histologically proved to be cutan melanoma. Interferon treatment was applied. She lost 8 kilograms in half a year which was caused not by the tumor progression, but hyperthyreoidism. A rapid clinical and laboratory improvement was observed for thyreostatic treatment and she regained her bodyweight. One year later she presented with a cough caused by pulmonary tumor. The tumor was surgically removed and histologically diagnosed as metastasis of melanoma. Cytostatic treatment was applied and she became asymptomatic. Four years after the diagnosis of melanoma she died of apoplexy. During the autopsy there was no sign of either melanoma or liver disease. CONCLUSIONS - The careful investigation of skin should be emphasised even in case of long established neurofibromatosis. The presented case shows an association of malignant melanoma and neurofibromatosis. In the background of loss of bodyweight even in a patient with history of malignant disease other causes should also be searched such as hyperthyreoidism especially during interferon therapy.

Original languageHungarian
Pages (from-to)349-352
Number of pages4
JournalLege Artis Medicinae
Issue number5
Publication statusPublished - máj. 1 2004



  • Hyperthyreosis
  • Interferon
  • Melanoma
  • Neurofibromatosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Folhoffer, A., Horváth, A., Csák, T., Nébenführer, L., Telkes, M., Iványi, A., & Szalay, F. (2004). Neurofibromatosis, melanoma malignum és hyperthyreosis egy HCV-pozitív betegen. Lege Artis Medicinae, 14(5), 349-352.