Neoplastic cells of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma lack the expression of follicular T-helper cell defining chemokine receptor CXCR5

Dóra Krenács, Annamária Bakos, László Török, Lajos Kocsis, Enikő Bagdi, László Krenács

Research output: Article

4 Citations (Scopus)

Abstract

Primary cutaneous CD4+ small/medium T-cell lymphoma (PCSM-TCL), a provisional peripheral T-cell lymphoma entity of the WHO-EORTC classification, is defined by the predominance of small-to-medium-sized CD4+ pleomorphic T cells without the features of mycosis fungoides (1–4), and is characterized by a non-epidermotropic polymorphic infiltrate presenting clusters of follicular T-helper (TFH) cell marker-positive atypical T cells (5–7). We report here that cluster-forming PD-1+ mediumto- large-sized T cells are the neoplastic cells of PCSMTCL; furthermore, these cells demonstrate cerebriform nuclei and lack the expression of TFH-cell defining C-X-C chemokine receptor CXCR5.

Original languageEnglish
Pages (from-to)850-852
Number of pages3
JournalActa Dermato-Venereologica
Volume96
Issue number6
DOIs
Publication statusPublished - szept. 2016

ASJC Scopus subject areas

  • Dermatology

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