Necroptosis: Biochemical, physiological and pathological aspects

Zsuzsanna Dunai, Pal I. Bauer, Rudolf Mihalik

Research output: Review article

40 Citations (Scopus)

Abstract

Programmed cell death is a key component of tissue homeostasis, normal development and wide variety of diseases. Conventional view refers to programmed cell death form as caspase-mediated apoptosis while necrosis is considered as an accidental and unwanted cell demise, carried out in a non-regulated manner and caused by extreme conditions. However, accumulating evidences indicate that necrotic cell death can also be a regulated process. The term necroptosis has been introduced to describe a cell death receptor-induced, caspase-independent, highly regulated type of programmed cell death process with morphological resemblance of necrosis. Necroptosis recently has been found to contribute to a wide range of pathologic cell death forms including ischemic brain injury, neurodegenerative diseases and viral infection, therefore a better understanding of the necroptotic signaling machinery has clinical relevance.

Original languageEnglish
Pages (from-to)791-800
Number of pages10
JournalPathology and Oncology Research
Volume17
Issue number4
DOIs
Publication statusPublished - dec. 1 2011

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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