NCX activity generates spontaneous Ca2+ oscillations in the astrocytic leaflet microdomain

László Héja, Julianna Kardos

Research output: Article

Abstract

The synergy between synaptic Glu release and astrocytic Glu-Na+ symport is essential to the signalling function of the tripartite synapse. Here we used kinetic data of astrocytic Glu transporters (EAAT) and the Na+/Ca2+ exchanger (NCX) to simulate Glu release, Glu uptake and subsequent Na+ and Ca2+ dynamics in the astrocytic leaflet microdomain following single release event. Model simulations show that Glu-Na+ symport differently affect intracellular [Na+] in synapses with different extent of astrocytic coverage. Surprisingly, NCX activity alone has been shown to generate markedly stable, spontaneous Ca2+ oscillation in the astrocytic leaflet. These on-going oscillations appear when NCX operates either in the forward or reverse direction. We conjecture that intrinsic NCX activity may play a prominent role in the generation of astrocytic Ca2+ oscillations.

Original languageEnglish
Article number102137
JournalCell Calcium
Volume86
DOIs
Publication statusPublished - márc. 2020

    Fingerprint

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this