Myofibroblast-derived SFRP1 as potential inhibitor of colorectal carcinoma field effect

Gábor Valcz, Árpád V. Patai, Alexandra Kalmár, Bálint Péterfia, István Furi, Barnabás Wichmann, Györgyi Muzes, Ferenc Sipos, Tibor Krenács, Emese Mihály, Sándor Spisák, Béla Molnár, Zsolt Tulassay

Research output: Article

24 Citations (Scopus)

Abstract

Epigenetic changes of stromal-epithelial interactions are of key importance in the regulation of colorectal carcinoma (CRC) cells and morphologically normal, but genetically and epigenetically altered epithelium in normal adjacent tumor (NAT) areas. Here we demonstrated retained protein expression of well-known Wnt inhibitor, secreted frizzled-related protein 1 (SFRP1) in stromal myofibroblasts and decreasing epithelial expression from NAT tissues towards the tumor. SFRP1 was unmethylated in laser microdissected myofibroblasts and partially hypermethylated in epithelial cells in these areas. In contrast, we found epigenetically silenced myofibroblast-derived SFRP1 in CRC stroma. Our results suggest that the myofibroblast-derived SFRP1 protein might be a paracrine inhibitor of epithelial proliferation in NAT areas and loss of this signal may support tumor proliferation in CRC.

Original languageEnglish
Article number106143
JournalPloS one
Volume9
Issue number11
DOIs
Publication statusPublished - nov. 18 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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