Mustard oil-induced cutaneous inflammation in the pig

G. Jancsó, F. K. Pierau, H. Sann

Research output: Article

11 Citations (Scopus)

Abstract

Recent findings indicate that chemical stimulation of the porcine skin with capsaicin evokes a flare response similar to that observed in man. The aim of the present study was to elucidate whether chemical stimulation of cutaneous capsaicin-sensitive nerve endings with mustard oil produces neurogenic inflammatory reactions in the pig. The application of mustard oil onto the abdominal skin of domestic pigs resulted in a pronounced flare response. After a previous intravenous injection of a solution of Evans blue, the skin area in contact with the irritant turned dark blue, indicating a marked extravasation of albumin. Quantitative estimation of the dye content of the skin supported this conclusion. The technique of vascular labelling revealed a delicate network of small subepidermal blood vessels in histological preparations after the application of mustard oil following a previous intravenous injection of colloidal silver. Labelled blood vessels were not noted outside the treated area. The present results show that mustard oil produces a strong cutaneous inflammatory response in the pig, and suggest that the porcine skin provides a valuable model for study of the significance of capsaicinsensitive sensory nerves in vascular and other cutaneous reactions.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalAgents and Actions
Volume39
Issue number1-2
DOIs
Publication statusPublished - máj. 1 1993

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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