Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: No association in patients from Germany, Hungary and Poland

Bernhard Greve, Rostislav Simonenko, Zsolt Illes, Agnes Peterfalvi, Nada Hamdi, Marcin P. Mycko, Krzysztof W. Selmaj, Csilla Rozsa, Katalin Rajczy, Peter Bauer, Klaus Berger, Robert Weissert

Research output: Article

17 Citations (Scopus)

Abstract

Polymorphisms in the CTLA4 gene region have been associated with susceptibility to autoimmune diseases. The recently described single nucleotide polymorphism CT60, located in the 3′ untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other autoimmune diseases. A case-control association study was conducted in German, Hungarian and Polish multiple sclerosis (MS) patients and regional control individuals for the CTLA4 CT60 and +49A/G polymorphisms. No significant association of these polymorphisms or respective haplotypes with MS was found. No association of CT60 genotypes with T cell expression of ICOS and CTLA-4 after in vitro stimulation was detected.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalMultiple Sclerosis
Volume14
Issue number2
DOIs
Publication statusPublished - márc. 1 2008

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Greve, B., Simonenko, R., Illes, Z., Peterfalvi, A., Hamdi, N., Mycko, M. P., Selmaj, K. W., Rozsa, C., Rajczy, K., Bauer, P., Berger, K., & Weissert, R. (2008). Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: No association in patients from Germany, Hungary and Poland. Multiple Sclerosis, 14(2), 153-158. https://doi.org/10.1177/1352458507082357