Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature

Gergely Varga, G. Mikala, László Gopcsa, Zoltán Csukly, Sarolta Kollai, György Balázs, Tímár Botond, Nikolett Wohner, Laura Horváth, Gergely Szombath, Péter Farkas, T. Masszi

Research output: Review article

1 Citation (Scopus)

Abstract

Central nervous system involvement is a rare complication of multiple myeloma with extremely poor prognosis as it usually fails to respond to therapy. We present 13 cases diagnosed at two centers in Budapest and review the current literature. The majority of our cases presented with high-risk features initially; two had plasma cell leukemia. Repeated genetic tests showed clonal evolution in 3 cases. Treatments varied according to the era, and efficacy was poor as generally reported in the literature. Only one patient is currently alive, with 3-month follow-up, and the patient responded to daratumumab-based treatment. Recent case reports show promising effectivity of pomalidomide and marizomib.

Original languageEnglish
Article number3970169
JournalJournal of Oncology
Volume2018
DOIs
Publication statusPublished - ápr. 23 2018

Fingerprint

Multiple Myeloma
Central Nervous System
Plasma Cell Leukemia
Clonal Evolution
Therapeutics

ASJC Scopus subject areas

  • Oncology

Cite this

Multiple Myeloma of the Central Nervous System : 13 Cases and Review of the Literature. / Varga, Gergely; Mikala, G.; Gopcsa, László; Csukly, Zoltán; Kollai, Sarolta; Balázs, György; Botond, Tímár; Wohner, Nikolett; Horváth, Laura; Szombath, Gergely; Farkas, Péter; Masszi, T.

In: Journal of Oncology, Vol. 2018, 3970169, 23.04.2018.

Research output: Review article

Varga, G, Mikala, G, Gopcsa, L, Csukly, Z, Kollai, S, Balázs, G, Botond, T, Wohner, N, Horváth, L, Szombath, G, Farkas, P & Masszi, T 2018, 'Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature', Journal of Oncology, vol. 2018, 3970169. https://doi.org/10.1155/2018/3970169
Varga, Gergely ; Mikala, G. ; Gopcsa, László ; Csukly, Zoltán ; Kollai, Sarolta ; Balázs, György ; Botond, Tímár ; Wohner, Nikolett ; Horváth, Laura ; Szombath, Gergely ; Farkas, Péter ; Masszi, T. / Multiple Myeloma of the Central Nervous System : 13 Cases and Review of the Literature. In: Journal of Oncology. 2018 ; Vol. 2018.
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