Multi-trichothecene mycotoxin exposure activates glutathione-redox system in broiler chicken

Csilla Pelyhe, Benjámin Kövesi, Erika Zándoki, Balázs Kovács, Márta Erdélyi, Szabina Kulcsár, M. Mézes, K. Balogh

Research output: Article

1 Citation (Scopus)


Co-occurrence of mycotoxin contamination of feeds is a frequent problem, therefore the purpose of this study was to evaluate the combined effect of T-2 toxin and deoxynivalenol (DON) on lipid peroxidation, parameters and regulation of the glutathione redox system in broiler chickens in a sub-chronic (7 day) study. The applied doses were: low mix: 0.23 mg T-2 toxin and 4.96 mg DON/kg feed; medium mix: 1.21 mg T-2 toxin and 12.38 mg DON/kg feed; and high mix: 2.42 T-2 toxin and 24.86 mg DON/kg feed. Liver samples were taken on days 0, 1, 2, 3, and 7 of the feeding trial. Lipid peroxidation decreased significantly as compared to the control on days 3 and 7 as effect of low and high doses, which can be related to the activation of the antioxidant system, which is supported by the elevated glutathione peroxidase activity and reduced glutathione concentration as compared to the control on day 3 in the medium and high dose groups. Gene expression of glutathione peroxidase 4 (GPX4) elevated on day 1 in a dose dependent manner, and showed continuous elevation in the highest dose group thereafter. The results suggested that common exposure of T-2 toxin and DON induced oxidative stress in the liver of broiler chickens, which activated the enzymatic antioxidant system, and consequently decreased lipid peroxidation.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
Publication statusPublished - okt. 1 2018

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Multi-trichothecene mycotoxin exposure activates glutathione-redox system in broiler chicken'. Together they form a unique fingerprint.

  • Cite this