MSC, a new benzoquinone-containing natural product with antimetastatic effect

M. Hídvégi, E. Rásó, Rita Tömösközi-Farkas, B. Szende, S. Paku, L. Prónai, József Bocsi, K. Lapis

Research output: Article

33 Citations (Scopus)

Abstract

An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR Oral administration (3g/leg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been observed in three metastasis models (3LL-HH, B16, HCR-25). The antimetastatic effect of MSC - besides the immune-reconstitution - may also be due to its cell adhesion inhibitory, cell proliferation inhibitory, apoptosis enhancing, and antioxidant characteristics, also observed in our in vitro experiments. It is even more noteworthy that combined treatment with MSC and one of the following antineoplastic agents (5-FU and DTIC) - both in wide use in every clay clinical practice - exhibited a significantly enhanced antimetastatic effect in appropriate metastasis models (established from C38 mouse colon carcinoma and B16 mouse melanoma respectively) as compared to the effect elicited by any component of these therapeutic compositions (MSC + 5-FU and MSC + DTIC) administered alone. The results show that the fermented wheat germ extract (MSC) has more than an additive effect and synergistically enhanced the metastasis inhibitory effect of both antineoplastic agents studied till now. It is also worthy of mention that the synchronous treatment with MSC profoundly decreased the toxic side effects of the applied antineoplastic agents (decreased weight loss etc). Based on the biological effects of MSC - shown to be non-toxic by subacute toxicology studies - this product may be used as an adjuvant in the therapy of malignant neoplasia and other diseases caused by or following immune-deficiency.

Original languageEnglish
Pages (from-to)277-289
Number of pages13
JournalCancer Biotherapy and Radiopharmaceuticals
Volume14
Issue number4
Publication statusPublished - 1999

Fingerprint

Biological Products
Antineoplastic Agents
Dacarbazine
Neoplasm Metastasis
Fluorouracil
Therapeutics
Experimental Melanomas
Skin Transplantation
Poisons
Lymphocyte Activation
Cell Adhesion
Toxicology
Triticum
Fermentation
Names
Oral Administration
Weight Loss
Leg
Colon
Antioxidants

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Oncology

Cite this

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title = "MSC, a new benzoquinone-containing natural product with antimetastatic effect",
abstract = "An orally applicable fermentation product of wheat germ containing 0.04{\%} substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR Oral administration (3g/leg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been observed in three metastasis models (3LL-HH, B16, HCR-25). The antimetastatic effect of MSC - besides the immune-reconstitution - may also be due to its cell adhesion inhibitory, cell proliferation inhibitory, apoptosis enhancing, and antioxidant characteristics, also observed in our in vitro experiments. It is even more noteworthy that combined treatment with MSC and one of the following antineoplastic agents (5-FU and DTIC) - both in wide use in every clay clinical practice - exhibited a significantly enhanced antimetastatic effect in appropriate metastasis models (established from C38 mouse colon carcinoma and B16 mouse melanoma respectively) as compared to the effect elicited by any component of these therapeutic compositions (MSC + 5-FU and MSC + DTIC) administered alone. The results show that the fermented wheat germ extract (MSC) has more than an additive effect and synergistically enhanced the metastasis inhibitory effect of both antineoplastic agents studied till now. It is also worthy of mention that the synchronous treatment with MSC profoundly decreased the toxic side effects of the applied antineoplastic agents (decreased weight loss etc). Based on the biological effects of MSC - shown to be non-toxic by subacute toxicology studies - this product may be used as an adjuvant in the therapy of malignant neoplasia and other diseases caused by or following immune-deficiency.",
keywords = "AVEMAR, Combination chemotherapy, Fermented wheat germ extract, Immune- reconstruction, Metastasis-inhibition, MSC, Substituted benzoquinone",
author = "M. H{\'i}dv{\'e}gi and E. R{\'a}s{\'o} and Rita T{\"o}m{\"o}sk{\"o}zi-Farkas and B. Szende and S. Paku and L. Pr{\'o}nai and J{\'o}zsef Bocsi and K. Lapis",
year = "1999",
language = "English",
volume = "14",
pages = "277--289",
journal = "Cancer Biotherapy and Radiopharmaceuticals",
issn = "1084-9785",
publisher = "Mary Ann Liebert Inc.",
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TY - JOUR

T1 - MSC, a new benzoquinone-containing natural product with antimetastatic effect

AU - Hídvégi, M.

AU - Rásó, E.

AU - Tömösközi-Farkas, Rita

AU - Szende, B.

AU - Paku, S.

AU - Prónai, L.

AU - Bocsi, József

AU - Lapis, K.

PY - 1999

Y1 - 1999

N2 - An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR Oral administration (3g/leg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been observed in three metastasis models (3LL-HH, B16, HCR-25). The antimetastatic effect of MSC - besides the immune-reconstitution - may also be due to its cell adhesion inhibitory, cell proliferation inhibitory, apoptosis enhancing, and antioxidant characteristics, also observed in our in vitro experiments. It is even more noteworthy that combined treatment with MSC and one of the following antineoplastic agents (5-FU and DTIC) - both in wide use in every clay clinical practice - exhibited a significantly enhanced antimetastatic effect in appropriate metastasis models (established from C38 mouse colon carcinoma and B16 mouse melanoma respectively) as compared to the effect elicited by any component of these therapeutic compositions (MSC + 5-FU and MSC + DTIC) administered alone. The results show that the fermented wheat germ extract (MSC) has more than an additive effect and synergistically enhanced the metastasis inhibitory effect of both antineoplastic agents studied till now. It is also worthy of mention that the synchronous treatment with MSC profoundly decreased the toxic side effects of the applied antineoplastic agents (decreased weight loss etc). Based on the biological effects of MSC - shown to be non-toxic by subacute toxicology studies - this product may be used as an adjuvant in the therapy of malignant neoplasia and other diseases caused by or following immune-deficiency.

AB - An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR Oral administration (3g/leg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been observed in three metastasis models (3LL-HH, B16, HCR-25). The antimetastatic effect of MSC - besides the immune-reconstitution - may also be due to its cell adhesion inhibitory, cell proliferation inhibitory, apoptosis enhancing, and antioxidant characteristics, also observed in our in vitro experiments. It is even more noteworthy that combined treatment with MSC and one of the following antineoplastic agents (5-FU and DTIC) - both in wide use in every clay clinical practice - exhibited a significantly enhanced antimetastatic effect in appropriate metastasis models (established from C38 mouse colon carcinoma and B16 mouse melanoma respectively) as compared to the effect elicited by any component of these therapeutic compositions (MSC + 5-FU and MSC + DTIC) administered alone. The results show that the fermented wheat germ extract (MSC) has more than an additive effect and synergistically enhanced the metastasis inhibitory effect of both antineoplastic agents studied till now. It is also worthy of mention that the synchronous treatment with MSC profoundly decreased the toxic side effects of the applied antineoplastic agents (decreased weight loss etc). Based on the biological effects of MSC - shown to be non-toxic by subacute toxicology studies - this product may be used as an adjuvant in the therapy of malignant neoplasia and other diseases caused by or following immune-deficiency.

KW - AVEMAR

KW - Combination chemotherapy

KW - Fermented wheat germ extract

KW - Immune- reconstruction

KW - Metastasis-inhibition

KW - MSC

KW - Substituted benzoquinone

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VL - 14

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EP - 289

JO - Cancer Biotherapy and Radiopharmaceuticals

JF - Cancer Biotherapy and Radiopharmaceuticals

SN - 1084-9785

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