Monitoring the pharmacokinetics of pyridinium aldoximes in the body

H. Kalász, J. Furész, K. Tekes

Research output: Article

9 Citations (Scopus)


A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis.

Original languageEnglish
Pages (from-to)596-610
Number of pages15
JournalMini-Reviews in Medicinal Chemistry
Issue number5
Publication statusPublished - szept. 21 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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