A (-)-deprenyl neuroprotektív hatásának molekuláris mechanizmusai

Melinda Pálfi, Éva Szöko, Kálmán Magyar

Research output: Article

4 Citations (Scopus)

Abstract

(-)-Deprenyl, the irreversible inhibitor of monoamine oxiclase B, has been used for decades in the therapy of Parkinson's disease. It improves parkinsonian symptoms due to its dopamine potentiating and antioxidant properties and presumedly delays disease progression. Its complex pharmacological action cannot be explained solely by its monoamine oxiclase B inhibitory property. Recently, (-)-deprenyl has been demonstrated to exert antiapoptotic, neuroprotective effects on a number of in vitro and in vivo models in a dose significantly lower than required for monoamine oxiclase B inhibition. (-)-Deprenyl and related propargylamines prevent apoptotic cell death by preserving the integrity of the mitochondrion that may be based on the activation of a complex transcriptional program. The changes in gene expression initiated by propargylamines incited to search for further possible target molecules that would explain more accurately the antiapoptotic effect of these compounds. The latest molecular targets include such classical metabolic enzymes, the homologues of which may participate in the regulation of gene expression as a part of transcriptional factor complexes. Some of the propargylamine targets - glyceralclehyde-3-phosphate dehydrogenase, poly(ADP-ribose) polymerase, nuclear amine oxidases - have already been demonstrated to be capable of transforming the metabolic changes in the cell to transcriptional responses. Data are accumulating about the relationship of these enzymes and propargyl compounds, but the real significance of this issue will only be established by future research.

Translated title of the contributionMolecular mechanisms of the neuroprotective of effect (-)-deprenyl
Original languageHungarian
Pages (from-to)1251-1257
Number of pages7
JournalOrvosi hetilap
Volume147
Issue number27
Publication statusPublished - júl. 9 2006

Keywords

  • (-)-deprenyl
  • Apoptosis
  • Gene transcription
  • Neuroprotection
  • Propargylamines

ASJC Scopus subject areas

  • Medicine(all)

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