Molecular mechanisms of apoptosis in the cardiac myocyte

Nanette H. Bishopric, P. Andréka, Tatiana Slepak, Keith A. Webster

Research output: Article

209 Citations (Scopus)

Abstract

Cardiac myocytes can undergo programmed cell death in response to a variety of insults and apoptotic elimination of myocytes from the adult myocardium can lead directly to cardiomyopathy and death. Although it remains to be shown that therapy specifically targeting apoptosis will improve the prognosis of ischemic heart disease or heart failure, a number of studies in the past year have shed light on potential ways to intervene in the process. Progress in the past year includes a better understanding of the importance of mitochondria-initiated events in cardiac myocyte apoptosis, of factors inducing apotosis during hypoxia, and of the dual pro-apoptotic and anti-apoptotic effects of hypertrophic stimuli such as β-adrenoceptor agonists, nitric oxide and calcineurin. Further evidence supports the pathophysiologic relevance of apoptosis in human heart disease. The tracking of cytoprotective and apoptotic signal transduction pathways has revealed important new insights into the roles of the mitogen-activated protein (MAP) kinases p38, extracellular signal regulated kinase (ERK) and c-Jun N-terminus kinase (JNK) in cardiac cell fate.

Original languageEnglish
Pages (from-to)141-150
Number of pages10
JournalCurrent Opinion in Pharmacology
Volume1
Issue number2
DOIs
Publication statusPublished - ápr. 1 2001

Fingerprint

Cardiac Myocytes
Apoptosis Inducing Factor
Apoptosis
Calcineurin
Extracellular Signal-Regulated MAP Kinases
p38 Mitogen-Activated Protein Kinases
Cardiomyopathies
Adrenergic Receptors
Muscle Cells
Myocardial Ischemia
Heart Diseases
Signal Transduction
Myocardium
Mitochondria
Nitric Oxide
Cell Death
Phosphotransferases
Heart Failure
Therapeutics
Hypoxia

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Molecular mechanisms of apoptosis in the cardiac myocyte. / Bishopric, Nanette H.; Andréka, P.; Slepak, Tatiana; Webster, Keith A.

In: Current Opinion in Pharmacology, Vol. 1, No. 2, 01.04.2001, p. 141-150.

Research output: Article

Bishopric, Nanette H. ; Andréka, P. ; Slepak, Tatiana ; Webster, Keith A. / Molecular mechanisms of apoptosis in the cardiac myocyte. In: Current Opinion in Pharmacology. 2001 ; Vol. 1, No. 2. pp. 141-150.
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