Molecular mechanisms and bioavailability of polyphenols in prostate cancer

Teodora Costea, Péter Nagy, Constanța Ganea, J. Szöllősi, Maria Magdalena Mocanu

Research output: Review article

3 Citations (Scopus)

Abstract

Prostate cancer is the one of the most frequently diagnosed cancers among men over the age of 50. Several lines of evidence support the observation that polyphenols have preventive and therapeutic effects in prostate cancer. Moreover, prostate cancer is ideal for chemoprevention due to its long latency. We propose here an equilibrated lifestyle with a diet rich in polyphenols as prophylactic attempts to slow down the progression of localized prostate cancer or prevent the occurrence of the disease. In this review, we will first summarize the molecular mechanisms of polyphenols in prostate cancer with a focus on the antioxidant and pro-oxidant effects, androgen receptors (AR), key molecules involved in AR signaling and their transactivation pathways, cell cycle, apoptosis, angiogenesis, metastasis, genetic aspects, and epigenetic mechanisms. The relevance of the molecular mechanisms is discussed in light of current bioavailability data regarding the activity of polyphenols in prostate cancer. We also highlight strategies for improving the bioavailability of polyphenols. We hope that this review will lead to further research regarding the bioavailability and the role of polyphenols in prostate cancer prevention and treatment.

Original languageEnglish
Article number1062
JournalInternational journal of molecular sciences
Volume20
Issue number5
DOIs
Publication statusPublished - márc. 1 2019

Fingerprint

bioavailability
Polyphenols
Biological Availability
Prostatic Neoplasms
cancer
Androgen Receptors
Cell death
Nutrition
Antioxidants
Oxidants
angiogenesis
Chemoprevention
diets
Therapeutic Uses
Reactive Oxygen Species
Epigenomics
antioxidants
apoptosis
metastasis
Transcriptional Activation

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Molecular mechanisms and bioavailability of polyphenols in prostate cancer. / Costea, Teodora; Nagy, Péter; Ganea, Constanța; Szöllősi, J.; Mocanu, Maria Magdalena.

In: International journal of molecular sciences, Vol. 20, No. 5, 1062, 01.03.2019.

Research output: Review article

Costea, Teodora ; Nagy, Péter ; Ganea, Constanța ; Szöllősi, J. ; Mocanu, Maria Magdalena. / Molecular mechanisms and bioavailability of polyphenols in prostate cancer. In: International journal of molecular sciences. 2019 ; Vol. 20, No. 5.
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