Abstract
Familial adenomatous polyposis (FAP) with an autosomal dominant inheritance has a particular importance among colorectal cancers. The first step in the development of familial adenomatous polyposis is the mutation of a tumor-suppressor APC gene, localised on the 21. region of the long arm of chromosome 5. The group of familial adenomatous polyposis includes the previously separated familial intestinal polyposis, Gardner-syndrome and most cases of Turcot-syndrome. Different mutations of the large APC gene explain the different clinical manifestations of familial adenomatous polyposis. The identification of the APC gene and/or its proteins can help the early, such as fetal diagnosis and more affective screening. Due to the understanding of the pathogenesis of familial adenomatous polyposis, there may be an euphenic prevention e.g. the longterm use of aspirin, the efficacy of which, is the goal of the European Union's CAPP programme inviting Hungarian familial adenomatous polyposis cases for participation, as well.
| Original language | Hungarian |
|---|---|
| Pages (from-to) | 808-813 |
| Number of pages | 6 |
| Journal | Lege Artis Medicinae |
| Volume | 7 |
| Issue number | 12 |
| Publication status | Published - 1997 |
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Keywords
- Aspirin prevention
- CAPP programme
- Colon polyposis registry
- Familial adenomatous polyposis
- Gene diagnostic test
ASJC Scopus subject areas
- Medicine(all)
Cite this
A familiaris adenomatosus polyposis molekularis genetikaja es az eufenikai megelozes lehetosege. / Ritter, L.; Tomcsik, M.; Czeizel, E.
In: Lege Artis Medicinae, Vol. 7, No. 12, 1997, p. 808-813.Research output: Article
}
TY - JOUR
T1 - A familiaris adenomatosus polyposis molekularis genetikaja es az eufenikai megelozes lehetosege
AU - Ritter, L.
AU - Tomcsik, M.
AU - Czeizel, E.
PY - 1997
Y1 - 1997
N2 - Familial adenomatous polyposis (FAP) with an autosomal dominant inheritance has a particular importance among colorectal cancers. The first step in the development of familial adenomatous polyposis is the mutation of a tumor-suppressor APC gene, localised on the 21. region of the long arm of chromosome 5. The group of familial adenomatous polyposis includes the previously separated familial intestinal polyposis, Gardner-syndrome and most cases of Turcot-syndrome. Different mutations of the large APC gene explain the different clinical manifestations of familial adenomatous polyposis. The identification of the APC gene and/or its proteins can help the early, such as fetal diagnosis and more affective screening. Due to the understanding of the pathogenesis of familial adenomatous polyposis, there may be an euphenic prevention e.g. the longterm use of aspirin, the efficacy of which, is the goal of the European Union's CAPP programme inviting Hungarian familial adenomatous polyposis cases for participation, as well.
AB - Familial adenomatous polyposis (FAP) with an autosomal dominant inheritance has a particular importance among colorectal cancers. The first step in the development of familial adenomatous polyposis is the mutation of a tumor-suppressor APC gene, localised on the 21. region of the long arm of chromosome 5. The group of familial adenomatous polyposis includes the previously separated familial intestinal polyposis, Gardner-syndrome and most cases of Turcot-syndrome. Different mutations of the large APC gene explain the different clinical manifestations of familial adenomatous polyposis. The identification of the APC gene and/or its proteins can help the early, such as fetal diagnosis and more affective screening. Due to the understanding of the pathogenesis of familial adenomatous polyposis, there may be an euphenic prevention e.g. the longterm use of aspirin, the efficacy of which, is the goal of the European Union's CAPP programme inviting Hungarian familial adenomatous polyposis cases for participation, as well.
KW - Aspirin prevention
KW - CAPP programme
KW - Colon polyposis registry
KW - Familial adenomatous polyposis
KW - Gene diagnostic test
UR - http://www.scopus.com/inward/record.url?scp=0031461301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031461301&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0031461301
VL - 7
SP - 808
EP - 813
JO - Lege Artis Medicinae
JF - Lege Artis Medicinae
SN - 0866-4811
IS - 12
ER -