Adenovírus 8-as típusa okozta járványos keratoconjunctivitis molekuláris diagnosztikája

Gábor Reuter, Edina Meleg, Gabriella Kiss, Nóra Albert, Zsuzsanna Fekete, György Szucs

Research output: Article

1 Citation (Scopus)

Abstract

Introduction: Both infectious and non-infectious forms of acute conjunctivitis are known. Viruses, especially different types of adenoviruses are the etiological agents of infectious epidemic conjunctivitis (conjunctivitis epidemica). Aims: The author's aims were to describe an outbreak of keratoconjunctivitis and to detect the viral agent by molecular methods in Hungary. Materials and Methods: Classical epidemiological methods were used for investigation. Polymerase chain reaction (PCR) followed by sequencing were used for the detection of adenoviral hexon region from freshly collected conjunctival swabs. Results: Between 9 October and 18 December 2006, a total of 60 patients became ill with keratoconjunctivitis in 7 settlements in Southwest Hungary. Mean age was 51,2 years. Conjunctivitis (100%), lacrimation (94%), foreign body sensation (83%), and dim vision (76%) were. the main clinical symptoms. Both eyes were affected in half of the cases. Direct contact was the main transmission route including nosocomial spread associated with ophtalmological practices. Five (62.5%) of 8 conjunctival swabs were PCR-positive for adenovirus; type 8 (HAdV8/ Baranya/2006/HUN; EF210714) which was genetically identical to adenovirus strain detected in Austria in 2004 (DQ149614). Conclusions: The outbreak of keratoconjunctivitis was partially associated with nosocomial infection caused by type 8 adenovirus. Both the recognition of the clinical illness, laboratory diagnosis and public health measures are necessary for the prevention of keratoconjunctivids infection and epidemic.

Original languageHungarian
Pages (from-to)1311-1315
Number of pages5
JournalOrvosi hetilap
Volume148
Issue number28
DOIs
Publication statusPublished - júl. 15 2007

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Keywords

  • Adenovirus type 8
  • Keratoconjunctivitis
  • Nosocomial
  • Outbreak

ASJC Scopus subject areas

  • Medicine(all)

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