Modulation of ionotropic glutamate receptor channels

L. Köles, K. Wirkner, P. Illes

Research output: Article

31 Citations (Scopus)

Abstract

Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory. Its dysfunction can be detected in epilepsy, stroke, neurodegenerative disorders and drug abuse. This paper summarizes the present knowledge on the modulation of glutamate-gated ion channels in the central nervous system by phosphorylation. An inhibitory interaction between adenosine A2A receptors and NMDA receptors in the neostriatum is described as an example, mediated by the phospholipase C/inositol trisphosphate/calmodulin and calmodulin kinase II pathway.

Original languageEnglish
Pages (from-to)925-932
Number of pages8
JournalNeurochemical Research
Volume26
Issue number8-9
DOIs
Publication statusPublished - 2001

Fingerprint

Ionotropic Glutamate Receptors
N-Methyl-D-Aspartate Receptors
Glutamic Acid
Modulation
Adenosine A2A Receptors
Ligand-Gated Ion Channels
Neostriatum
Kainic Acid Receptors
Calcium-Calmodulin-Dependent Protein Kinases
Phosphorylation
Metabotropic Glutamate Receptors
AMPA Receptors
Neurology
Type C Phospholipases
Inositol
Calmodulin
Ion Channels
GTP-Binding Proteins
Neurodegenerative Diseases
Substance-Related Disorders

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Modulation of ionotropic glutamate receptor channels. / Köles, L.; Wirkner, K.; Illes, P.

In: Neurochemical Research, Vol. 26, No. 8-9, 2001, p. 925-932.

Research output: Article

Köles, L. ; Wirkner, K. ; Illes, P. / Modulation of ionotropic glutamate receptor channels. In: Neurochemical Research. 2001 ; Vol. 26, No. 8-9. pp. 925-932.
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