Modulation of hypercholesterolemia-induced oxidative/nitrative stress in the heart

Csaba Csonka, Márta Sárközy, Márton Pipicz, László Dux, Tamás Csont

Research output: Review article

36 Citations (Scopus)

Abstract

Hypercholesterolemia is a frequent metabolic disorder associated with increased risk for cardiovascular morbidity and mortality. In addition to its well-known proatherogenic effect, hypercholesterolemia may exert direct effects on the myocardium resulting in contractile dysfunction, aggravated ischemia/reperfusion injury, and diminished stress adaptation. Both preclinical and clinical studies suggested that elevated oxidative and/or nitrative stress plays a key role in cardiac complications induced by hypercholesterolemia. Therefore, modulation of hypercholesterolemia-induced myocardial oxidative/nitrative stress is a feasible approach to prevent or treat deleterious cardiac consequences. In this review, we discuss the effects of various pharmaceuticals, nutraceuticals, some novel potential pharmacological approaches, and physical exercise on hypercholesterolemia-induced oxidative/nitrative stress and subsequent cardiac dysfunction as well as impaired ischemic stress adaptation of the heart in hypercholesterolemia.

Original languageEnglish
Article number3863726
JournalOxidative medicine and cellular longevity
Volume2016
DOIs
Publication statusPublished - jan. 1 2016

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ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

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