Minor physical anomalies in affective disorders. A review of the literature

T. Tényi, M. Trixler, Györgyi Csábi

Research output: Article

25 Citations (Scopus)

Abstract

Background: The increased frequency of MPAs may be external markers of abnormal brain development in affective disorders. Methods: A MEDLINE, psychInfo and Web of Science search was evaluated to collect all publications on the prevalence of minor physical anomalies in bipolar affective disorder and unipolar major depression. Aims: As reports on the prevalence of MPAs in affective disorders were controversial, were based on highly different number of patients and were evaluated by the use of scales with different sensitivities, we considered as important to review the current state of knowledge and to recommend directions to further research. Results: 14 publications on 12 studies were found after a careful literature search. 5 studies have dealt with the prevalence of MPAs in bipolar affective disorder, 3 have reported on examinations among patients with unipolar major depression, while 5 publications on 3 studies combined patients with bipolar affective disorder, schizoaffective disorder and unipolar major depression. 1 study was published on the prevalence of MPAs among mood disorders, without the differentiation of the data of patients with bipolar affective disorder and unipolar major depression. Limitations: Few studies with relatively small size were published, there is no data on the distinction between bipolar I and bipolar II disorders. Conclusion: The reviewed data suggest a higher probability of the role of an aberrant neurodevelopment in bipolar affective disorder and a smaller in unipolar major depression.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalJournal of Affective Disorders
Volume112
Issue number1-3
DOIs
Publication statusPublished - jan. 2009

Fingerprint

Mood Disorders
Bipolar Disorder
Depressive Disorder
Publications
MEDLINE
Psychotic Disorders
Brain
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Minor physical anomalies in affective disorders. A review of the literature. / Tényi, T.; Trixler, M.; Csábi, Györgyi.

In: Journal of Affective Disorders, Vol. 112, No. 1-3, 01.2009, p. 11-18.

Research output: Article

@article{626d281f05b34ca589a3dec9a56fdea5,
title = "Minor physical anomalies in affective disorders. A review of the literature",
abstract = "Background: The increased frequency of MPAs may be external markers of abnormal brain development in affective disorders. Methods: A MEDLINE, psychInfo and Web of Science search was evaluated to collect all publications on the prevalence of minor physical anomalies in bipolar affective disorder and unipolar major depression. Aims: As reports on the prevalence of MPAs in affective disorders were controversial, were based on highly different number of patients and were evaluated by the use of scales with different sensitivities, we considered as important to review the current state of knowledge and to recommend directions to further research. Results: 14 publications on 12 studies were found after a careful literature search. 5 studies have dealt with the prevalence of MPAs in bipolar affective disorder, 3 have reported on examinations among patients with unipolar major depression, while 5 publications on 3 studies combined patients with bipolar affective disorder, schizoaffective disorder and unipolar major depression. 1 study was published on the prevalence of MPAs among mood disorders, without the differentiation of the data of patients with bipolar affective disorder and unipolar major depression. Limitations: Few studies with relatively small size were published, there is no data on the distinction between bipolar I and bipolar II disorders. Conclusion: The reviewed data suggest a higher probability of the role of an aberrant neurodevelopment in bipolar affective disorder and a smaller in unipolar major depression.",
keywords = "Biological markers, Bipolar affective disorder, Minor physical anomalies, Neurodevelopment, Unipolar major depression",
author = "T. T{\'e}nyi and M. Trixler and Gy{\"o}rgyi Cs{\'a}bi",
year = "2009",
month = "1",
doi = "10.1016/j.jad.2008.04.025",
language = "English",
volume = "112",
pages = "11--18",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Minor physical anomalies in affective disorders. A review of the literature

AU - Tényi, T.

AU - Trixler, M.

AU - Csábi, Györgyi

PY - 2009/1

Y1 - 2009/1

N2 - Background: The increased frequency of MPAs may be external markers of abnormal brain development in affective disorders. Methods: A MEDLINE, psychInfo and Web of Science search was evaluated to collect all publications on the prevalence of minor physical anomalies in bipolar affective disorder and unipolar major depression. Aims: As reports on the prevalence of MPAs in affective disorders were controversial, were based on highly different number of patients and were evaluated by the use of scales with different sensitivities, we considered as important to review the current state of knowledge and to recommend directions to further research. Results: 14 publications on 12 studies were found after a careful literature search. 5 studies have dealt with the prevalence of MPAs in bipolar affective disorder, 3 have reported on examinations among patients with unipolar major depression, while 5 publications on 3 studies combined patients with bipolar affective disorder, schizoaffective disorder and unipolar major depression. 1 study was published on the prevalence of MPAs among mood disorders, without the differentiation of the data of patients with bipolar affective disorder and unipolar major depression. Limitations: Few studies with relatively small size were published, there is no data on the distinction between bipolar I and bipolar II disorders. Conclusion: The reviewed data suggest a higher probability of the role of an aberrant neurodevelopment in bipolar affective disorder and a smaller in unipolar major depression.

AB - Background: The increased frequency of MPAs may be external markers of abnormal brain development in affective disorders. Methods: A MEDLINE, psychInfo and Web of Science search was evaluated to collect all publications on the prevalence of minor physical anomalies in bipolar affective disorder and unipolar major depression. Aims: As reports on the prevalence of MPAs in affective disorders were controversial, were based on highly different number of patients and were evaluated by the use of scales with different sensitivities, we considered as important to review the current state of knowledge and to recommend directions to further research. Results: 14 publications on 12 studies were found after a careful literature search. 5 studies have dealt with the prevalence of MPAs in bipolar affective disorder, 3 have reported on examinations among patients with unipolar major depression, while 5 publications on 3 studies combined patients with bipolar affective disorder, schizoaffective disorder and unipolar major depression. 1 study was published on the prevalence of MPAs among mood disorders, without the differentiation of the data of patients with bipolar affective disorder and unipolar major depression. Limitations: Few studies with relatively small size were published, there is no data on the distinction between bipolar I and bipolar II disorders. Conclusion: The reviewed data suggest a higher probability of the role of an aberrant neurodevelopment in bipolar affective disorder and a smaller in unipolar major depression.

KW - Biological markers

KW - Bipolar affective disorder

KW - Minor physical anomalies

KW - Neurodevelopment

KW - Unipolar major depression

UR - http://www.scopus.com/inward/record.url?scp=56249138610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56249138610&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2008.04.025

DO - 10.1016/j.jad.2008.04.025

M3 - Article

C2 - 18508129

AN - SCOPUS:56249138610

VL - 112

SP - 11

EP - 18

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1-3

ER -