Minimal Clinically Important Difference on Parkinson's Disease Sleep Scale 2nd Version

Krisztina Horváth, Zsuzsanna Aschermann, Péter Ács, Gabriella Deli, József Janszky, Sámuel Komoly, Kázmér Karádi, Márton Kovács, Attila Makkos, Béla Faludi, Norbert Kovács

Research output: Article

9 Citations (Scopus)


Background and Aims. The aim of the present study was to determine the estimates of minimal clinically important difference for Parkinson's Disease Sleep Scale 2nd version (PDSS-2) total score and dimensions. Methods. The subject population consisted of 413 PD patients. At baseline, MDS-UPDRS, Hoehn-Yahr Scale, Mattis Dementia Rating Scale, and PDSS-2 were assessed. Nine months later the PDSS-2 was reevaluated with the Patient-Reported Global Impression Improvement Scale. Both anchor-based techniques (within patients' score change method and sensitivity- and specificity-based method by receiver operating characteristic analysis) and distribution-based approaches (effect size calculations) were utilized to determine the magnitude of minimal clinically important difference. Results. According to our results, any improvements larger than -3.44 points or worsening larger than 2.07 points can represent clinically important changes for the patients. These thresholds have the effect size of 0.21 and -0.21, respectively. Conclusions. Minimal clinically important differences are the smallest change of scores that are subjectively meaningful to patients. Studies using the PDSS-2 as outcome measure should utilize the threshold of -3.44 points for detecting improvement or the threshold of 2.07 points for observing worsening.

Original languageEnglish
Article number970534
JournalParkinson's Disease
Publication statusPublished - jan. 1 2015

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

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    Horváth, K., Aschermann, Z., Ács, P., Deli, G., Janszky, J., Komoly, S., Karádi, K., Kovács, M., Makkos, A., Faludi, B., & Kovács, N. (2015). Minimal Clinically Important Difference on Parkinson's Disease Sleep Scale 2nd Version. Parkinson's Disease, 2015, [970534].