A felnóttkori coeliakia felismerésének lehetósége szúróvizsgálatok alkalmazásával immunológiai szakambulancián jelentkezó betegekben.

Katalin Kilián, Kata Miklós, Katalin Rajczy, Andrea Sipos, Lilla Lengyel, László Nemes, Gyözö Petrányi, Katalin Pálóczi

Research output: Article

2 Citations (Scopus)

Abstract

INTRODUCTION: Coeliac disease (gluten sensitive enteropathy) is a very frequent disease appearing in variegated clinical form. In the last decade--concerning the immunogenetic and immunopathological aspects of the disease many of new recognition came to alight. AIM: As the disease can lay hidden in its non classical manifesting form for a very long time, authors wished to study the efficacy of screening, which may be introduced for patients attending immunological outpatient care service. PATIENTS, METHODS AND RESULTS: In the frame of nation-wide patient care, out of the 200 potential patients sent for immunological check up, various form of coeliac disease was diagnosed in 20 cases. Among these cases there are two--presented for the first time--which are connected to bone marrow transplantation. Based on the immunogenetics and autoantibody serology as well as on small intestine biopsies the following conclusions were made. CONCLUSION: 1. Coeliac disease in Hungary is very frequent. Hidden disease should be considered first of all in cases of malabsorption symptoms. 2. Demonstration of autoantibodies on wide-scale palette helps to state the diagnosis based on the systematic auto-immune disease connection. 3. Study of Human Leukocyte Antigen allotype (HLA-DQA1*0501/DQBI*02) applied as marker can considerably support the suspicion of disease. 4. Histology test of the small intestine cannot be omitted.

Original languageHungarian
Pages (from-to)1069-1076
Number of pages8
JournalOrvosi hetilap
Volume144
Issue number22
Publication statusPublished - jún. 1 2003

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ASJC Scopus subject areas

  • Medicine(all)

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