Metabolic effect of interferon preparations and some interferon inducers: activation of adenylate cyclase system

I. Mecs, M. Kasler, A. Lozsa, G. Kovacs

Research output: Article

11 Citations (Scopus)

Abstract

Crude or purified mouse interferon preparations activate adenylate cyclase and raise the level of 3'5' cAMP in L cells, though this activity does not parallel the antiviral capacity of the preparations. Poly I:poly C and poly A:poly U also activate adenylate cyclase and the effect seems to be correlated with the molecular size of the polymers. DEAE dextran, a polycationic substance, proved to be an effective activator of adenylate cyclase. The effect of the inducers and activators administered simultaneously seems to be additive.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalActa microbiologica Academiae Scientiarum Hungaricae
Volume21
Issue number3-4
Publication statusPublished - dec. 1 1974

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ASJC Scopus subject areas

  • Medicine(all)

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