Metabolic and endocrine characteristics of pregnancy toxemia in the ferret

A. Prohaczik, M. Kulcsár, G. Huszenicza

Research output: Article

6 Citations (Scopus)

Abstract

Metabolic and endocrine characteristics of pregnancy toxemia are well documented in small ruminants, but less known in other species. The objective of this study was to measure plasma levels of certain metabolites and metabolic hormones related to the energetic status in blood from sick and healthy, non-pregnant (control) ferrets. Blood was collected from moribund, hypothermic, late pregnant females suffering from pregnancy toxemia (n = 4) and from healthy female ferrets (n = 14) to measure glucose, ketone (βOH-butyrate, BHB), insulin, thyroxine (T4) and 3,3',5-triiodothyronine (T3) concentrations. In contrast to healthy animals, hypoglycemia, hyperketonemia, hypoinsulinemia and decreased T4 and T3 levels were detected in females with pregnancy toxemia and necropsy showed excessive hepatic lipidosis. In summary, it can be concluded that pregnancy toxemia caused by a negative energy balance in ferrets resembles the late-gestational hyperketonemia of twin-pregnant ewes, and moreover that similar endocrine changes may occur.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalVeterinarni Medicina
Volume54
Issue number2
Publication statusPublished - febr. 2009

Fingerprint

pregnancy toxemia
Ferrets
ferrets
Pre-Eclampsia
triiodothyronine
hyperketonemia
L-thyroxine
Reverse Triiodothyronine
Lipidoses
hypoglycemia
Butyrates
blood
Ruminants
small ruminants
thyroxine
butyrates
ketones
Ketones
Thyroxine
Hypoglycemia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Metabolic and endocrine characteristics of pregnancy toxemia in the ferret",
abstract = "Metabolic and endocrine characteristics of pregnancy toxemia are well documented in small ruminants, but less known in other species. The objective of this study was to measure plasma levels of certain metabolites and metabolic hormones related to the energetic status in blood from sick and healthy, non-pregnant (control) ferrets. Blood was collected from moribund, hypothermic, late pregnant females suffering from pregnancy toxemia (n = 4) and from healthy female ferrets (n = 14) to measure glucose, ketone (βOH-butyrate, BHB), insulin, thyroxine (T4) and 3,3',5-triiodothyronine (T3) concentrations. In contrast to healthy animals, hypoglycemia, hyperketonemia, hypoinsulinemia and decreased T4 and T3 levels were detected in females with pregnancy toxemia and necropsy showed excessive hepatic lipidosis. In summary, it can be concluded that pregnancy toxemia caused by a negative energy balance in ferrets resembles the late-gestational hyperketonemia of twin-pregnant ewes, and moreover that similar endocrine changes may occur.",
keywords = "3,3',5-triiodo-thyronine (T), Gestational ketosis, Insulin, Thyroxine (T)",
author = "A. Prohaczik and M. Kulcs{\'a}r and G. Huszenicza",
year = "2009",
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journal = "Veterinarni Medicina",
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TY - JOUR

T1 - Metabolic and endocrine characteristics of pregnancy toxemia in the ferret

AU - Prohaczik, A.

AU - Kulcsár, M.

AU - Huszenicza, G.

PY - 2009/2

Y1 - 2009/2

N2 - Metabolic and endocrine characteristics of pregnancy toxemia are well documented in small ruminants, but less known in other species. The objective of this study was to measure plasma levels of certain metabolites and metabolic hormones related to the energetic status in blood from sick and healthy, non-pregnant (control) ferrets. Blood was collected from moribund, hypothermic, late pregnant females suffering from pregnancy toxemia (n = 4) and from healthy female ferrets (n = 14) to measure glucose, ketone (βOH-butyrate, BHB), insulin, thyroxine (T4) and 3,3',5-triiodothyronine (T3) concentrations. In contrast to healthy animals, hypoglycemia, hyperketonemia, hypoinsulinemia and decreased T4 and T3 levels were detected in females with pregnancy toxemia and necropsy showed excessive hepatic lipidosis. In summary, it can be concluded that pregnancy toxemia caused by a negative energy balance in ferrets resembles the late-gestational hyperketonemia of twin-pregnant ewes, and moreover that similar endocrine changes may occur.

AB - Metabolic and endocrine characteristics of pregnancy toxemia are well documented in small ruminants, but less known in other species. The objective of this study was to measure plasma levels of certain metabolites and metabolic hormones related to the energetic status in blood from sick and healthy, non-pregnant (control) ferrets. Blood was collected from moribund, hypothermic, late pregnant females suffering from pregnancy toxemia (n = 4) and from healthy female ferrets (n = 14) to measure glucose, ketone (βOH-butyrate, BHB), insulin, thyroxine (T4) and 3,3',5-triiodothyronine (T3) concentrations. In contrast to healthy animals, hypoglycemia, hyperketonemia, hypoinsulinemia and decreased T4 and T3 levels were detected in females with pregnancy toxemia and necropsy showed excessive hepatic lipidosis. In summary, it can be concluded that pregnancy toxemia caused by a negative energy balance in ferrets resembles the late-gestational hyperketonemia of twin-pregnant ewes, and moreover that similar endocrine changes may occur.

KW - 3,3',5-triiodo-thyronine (T)

KW - Gestational ketosis

KW - Insulin

KW - Thyroxine (T)

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