Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting

James J. Dinicolantonio, Craig J. Beavers, Arthur R. Menezes, Carl J. Lavie, James H. O'Keefe, Pascal Meier, András Vorobcsuk, D. Aradi, A. Komócsi, Saurav Chatterjee, Fabrizio D'Ascenzo, Mauro Gasparini, Jasper Brugts, Giuseppe Biondi-Zoccai

Research output: Article

27 Citations (Scopus)

Abstract

A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.

Original languageEnglish
Pages (from-to)565-569
Number of pages5
JournalThe American journal of cardiology
Volume113
Issue number3
DOIs
Publication statusPublished - febr. 1 2014

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Metoprolol
Coronary Artery Bypass
Atrial Fibrillation
Meta-Analysis
Incidence
Randomized Controlled Trials
PubMed
MEDLINE
Odds Ratio
Confidence Intervals
carvedilol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting. / Dinicolantonio, James J.; Beavers, Craig J.; Menezes, Arthur R.; Lavie, Carl J.; O'Keefe, James H.; Meier, Pascal; Vorobcsuk, András; Aradi, D.; Komócsi, A.; Chatterjee, Saurav; D'Ascenzo, Fabrizio; Gasparini, Mauro; Brugts, Jasper; Biondi-Zoccai, Giuseppe.

In: The American journal of cardiology, Vol. 113, No. 3, 01.02.2014, p. 565-569.

Research output: Article

Dinicolantonio, JJ, Beavers, CJ, Menezes, AR, Lavie, CJ, O'Keefe, JH, Meier, P, Vorobcsuk, A, Aradi, D, Komócsi, A, Chatterjee, S, D'Ascenzo, F, Gasparini, M, Brugts, J & Biondi-Zoccai, G 2014, 'Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting', The American journal of cardiology, vol. 113, no. 3, pp. 565-569. https://doi.org/10.1016/j.amjcard.2013.10.020
Dinicolantonio, James J. ; Beavers, Craig J. ; Menezes, Arthur R. ; Lavie, Carl J. ; O'Keefe, James H. ; Meier, Pascal ; Vorobcsuk, András ; Aradi, D. ; Komócsi, A. ; Chatterjee, Saurav ; D'Ascenzo, Fabrizio ; Gasparini, Mauro ; Brugts, Jasper ; Biondi-Zoccai, Giuseppe. / Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting. In: The American journal of cardiology. 2014 ; Vol. 113, No. 3. pp. 565-569.
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