Mercury-induced alterations in rat kidneys and testes in vivo

Peter Massanyi, Norbert Lukac, Jana Slivkova, Jaroslav Kovacik, Alexander V. Makarevich, Peter Chrenek, Robert Toman, Z. Forgács, Z. Somosy, Robert Stawarz, Grzegorz Formicki

Research output: Article

20 Citations (Scopus)

Abstract

In this study effects of mercury administration on the kidney and testicular structure of adult rats were evaluated. Rats received mercury (HgCl2) in single intraperitoneal dose 20 mg HgCl2 (group A), 10 mg HgCl2 (group B) and 5 mg HgCl2 (group C) per kilogram of body weight and were killed after 48 hours following mercury administration. After the preparation of histological samples the results were compared with control group (K). In kidney decreased diameters of glomeruli and renal corpuscles, damaged tubules with affected quality of tubular cells and infiltration of interstitium were detected. Quantitative analysis demonstrated increased relative volume of tubules and renal corpuscles. Also the number of nuclei and glomeruli was increased in all experimental groups. The diameter of glomeruli and renal corpuscles was decreased. In testis undulation of basal membrane, dilatation of blood vessels in interstitium and occurrence of empty spaces in germinal epithelium were observed. Decreased relative volume of germinal epithelium, increased relative volume of interstitium and increased apoptosis occurrence suggest damaged interstitium and revealed occurrence of edemas. The relative volume of seminiferous tubules showed higher luminization. The number of nuclei was decreased in all experimental groups what is in positive relation with occurrence of empty spaces. Also other evaluated criteria demonstrated significant differences between control group and experimental groups. This study reports a negative effect of mercury on the structure and function of kidney and testes.

Original languageEnglish
Pages (from-to)865-870
Number of pages6
JournalJournal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
Volume42
Issue number7
DOIs
Publication statusPublished - jún. 2007

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Mercuric Chloride
Mercury
Rats
Blood vessels
Cell death
Infiltration
Membranes
apoptosis
Chemical analysis
quantitative analysis
vessel
infiltration
blood
Apoptosis
membrane
mercury
effect

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Science(all)
  • Environmental Chemistry

Cite this

Mercury-induced alterations in rat kidneys and testes in vivo. / Massanyi, Peter; Lukac, Norbert; Slivkova, Jana; Kovacik, Jaroslav; Makarevich, Alexander V.; Chrenek, Peter; Toman, Robert; Forgács, Z.; Somosy, Z.; Stawarz, Robert; Formicki, Grzegorz.

In: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, Vol. 42, No. 7, 06.2007, p. 865-870.

Research output: Article

Massanyi, Peter ; Lukac, Norbert ; Slivkova, Jana ; Kovacik, Jaroslav ; Makarevich, Alexander V. ; Chrenek, Peter ; Toman, Robert ; Forgács, Z. ; Somosy, Z. ; Stawarz, Robert ; Formicki, Grzegorz. / Mercury-induced alterations in rat kidneys and testes in vivo. In: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering. 2007 ; Vol. 42, No. 7. pp. 865-870.
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