Mediastinal bulky tumour in Hodgkin's disease and prognostic value of positron emission tomography in the evaluation of post-treatment residual masses

Katalin Keresztes, Zsolt Lengyel, Katalin Devenyi, Györgyi Vadasz, Zsofia Miltenyi, Arpad Illes

Research output: Article

13 Citations (Scopus)

Abstract

Among the 193 patients (82 female, 111 male) treated primarily for Hodgkin's disease at our clinic between 1990 and 2001 and followed up until 2003, 42 (22%) had mediastinal bulky tumours (MBTs) by the Cotswolds criteria. The rate of MBT diagnosis was significantly greater in the early stage of the disease, these patients were younger and - in contrast to the other group - they all received combined therapy. No significant differences were found in the overall and relapse-free survival rate in the two groups, but relapse and death rates were lower in the patients with bulky tumours. Of the total number of patients, 27 underwent a total of 31 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) examinations, mainly for the evaluation of post-treatment residual mass viability. In the 12 positive cases, the majority of patients received further therapy. During the mean follow-up time of 58 months (range 5-98 months) after obtaining negative results, progression of the disease was found in 2 cases 14 and 23 months later, respectively. Based on our results, we conclude that FDG-PET examinations show a good correlation with clinical follow-up results.

Original languageEnglish
Pages (from-to)194-199
Number of pages6
JournalActa Haematologica
Volume112
Issue number4
DOIs
Publication statusPublished - dec. 3 2004

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ASJC Scopus subject areas

  • Hematology

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