Median raphe controls acquisition of negative experience in the mouse

András Szo, Krisztián Zichó, Albert M. Barth, Roland T. Gönczi, Dániel Schlingloff, Bibiána Török, Eszter Sipos, Abel Major, Zsuzsanna Bardóczi, Katalin E. Sos, Attila I. Gulyás, Viktor Varga, Dóra Zelena, Tamás F. Freund, Gábor Nyiri

Research output: Article

2 Citations (Scopus)

Abstract

Adverse events need to be quickly evaluated and memorized, yet how these processes are coordinated is poorly understood. We discovered a large population of excitatory neurons in mouse median raphe region (MRR) expressing vesicular glutamate transporter 2 (vGluT2) that received inputs from several negative experience–related brain centers, projected to the main aversion centers, and activated the septohippocampal system pivotal for learning of adverse events. These neurons were selectively activated by aversive but not rewarding stimuli. Their stimulation induced place aversion, aggression, depression-related anhedonia, and suppression of reward-seeking behavior and memory acquisition–promoting hippocampal theta oscillations. By contrast, their suppression impaired both contextual and cued fear memory formation. These results suggest that MRR vGluT2 neurons are crucial for the acquisition of negative experiences and may play a central role in depression-related mood disorders.

Original languageEnglish
Article numbereaay8746
JournalScience
Volume366
Issue number6469
DOIs
Publication statusPublished - nov. 29 2019

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Vesicular Glutamate Transport Protein 2
Neurons
Depression
Anhedonia
Aggression
Mood Disorders
Reward
Fear
Learning
Brain
Population

ASJC Scopus subject areas

  • General

Cite this

Szo, A., Zichó, K., Barth, A. M., Gönczi, R. T., Schlingloff, D., Török, B., ... Nyiri, G. (2019). Median raphe controls acquisition of negative experience in the mouse. Science, 366(6469), [eaay8746]. https://doi.org/10.1126/science.aay8746

Median raphe controls acquisition of negative experience in the mouse. / Szo, András; Zichó, Krisztián; Barth, Albert M.; Gönczi, Roland T.; Schlingloff, Dániel; Török, Bibiána; Sipos, Eszter; Major, Abel; Bardóczi, Zsuzsanna; Sos, Katalin E.; Gulyás, Attila I.; Varga, Viktor; Zelena, Dóra; Freund, Tamás F.; Nyiri, Gábor.

In: Science, Vol. 366, No. 6469, eaay8746, 29.11.2019.

Research output: Article

Szo, A, Zichó, K, Barth, AM, Gönczi, RT, Schlingloff, D, Török, B, Sipos, E, Major, A, Bardóczi, Z, Sos, KE, Gulyás, AI, Varga, V, Zelena, D, Freund, TF & Nyiri, G 2019, 'Median raphe controls acquisition of negative experience in the mouse', Science, vol. 366, no. 6469, eaay8746. https://doi.org/10.1126/science.aay8746
Szo A, Zichó K, Barth AM, Gönczi RT, Schlingloff D, Török B et al. Median raphe controls acquisition of negative experience in the mouse. Science. 2019 nov. 29;366(6469). eaay8746. https://doi.org/10.1126/science.aay8746
Szo, András ; Zichó, Krisztián ; Barth, Albert M. ; Gönczi, Roland T. ; Schlingloff, Dániel ; Török, Bibiána ; Sipos, Eszter ; Major, Abel ; Bardóczi, Zsuzsanna ; Sos, Katalin E. ; Gulyás, Attila I. ; Varga, Viktor ; Zelena, Dóra ; Freund, Tamás F. ; Nyiri, Gábor. / Median raphe controls acquisition of negative experience in the mouse. In: Science. 2019 ; Vol. 366, No. 6469.
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