Maternal factors in the origin of isolated anorectal malformations - A population-based case-control study

Gabor Vermes, Daniel László, Ákos Mátrai, Andrew E. Czeizel, Nándor Ács

Research output: Article

4 Citations (Scopus)

Abstract

Objective: In most patients affected by isolated anorectal malformation (IARM), the etiology is unknown. Thus, the aim of this study was to analyze the possible role of maternal risk factors in the origin of IARM.Methods: The study samples included 231 cases with IARM, 361 matched and 38 151 population controls without any defect in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. Cases with IARM were evaluated in the function of maternal diseases and related drug use.Results: The findings of this case-control study suggested that cases with IARM have an obvious male excess. The mothers of cases with IARM had a lower incidence of severe nausea and vomiting in pregnancy and a higher incidence of acute infectious diseases in the urinary tract.Conclusions: Lack of nausea and vomiting in pregnancy and the higher incidence of urinary tract infections may have a role in the development of IARM.

Original languageEnglish
Pages (from-to)2316-2321
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume29
Issue number14
DOIs
Publication statusPublished - júl. 17 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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