In order to study the putative monoamine oxidase (MAO) inhibitory side effect of neuroleptics and simultaneous changes in platelet serotonin content both MAO-B activity and serotonin (5-HT) content in platelets of 30 healthy volunteers and 50 schizophrenic patients treated with neuroleptics were investigated. Our results have shown significantly lower MAO-B activity (15.26 ± 6.81 S.D. vs. 8.63 ± 3.82mmol/hour/109 platelets) and higher platelet 5-HT content (906.19 ± 285.33 vs. 1,727.85 ± 947.40ng/109 platelets) in the schizophrenic group. Platelet MAO-B activity was considerably lower in paranoid and residual schizophrenics compared with other patients, however, no difference was found in platelet 5-HT content between different subtypes of schizophrenia. Various neuroleptic treatments did not produce different effects either on platelet serotonin content or platelet MAO-B activity.
|Number of pages||7|
|Journal||Journal of Neural Transmission, Supplement|
|Publication status||Published - ápr. 29 1998|
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry