MAO activity, serotonin metabolism and aggregation of platelets from migraine patients. A preliminary study.

K. Kovács, L. Tóthfalusi, F. Hermán, K. Magyar

Research output: Article

6 Citations (Scopus)

Abstract

Platelets of migraine patients showed abnormal behavior such as hyperaggregability and reduced monoamine oxidase activity (MAO). We measured the MAO activity, serotonin (5-HT) content and release, adenosine diphosphate (ADP)-induced aggregation, and the prostacyclin (PGI2) antiaggregatory effect using the same sample of platelets from migraine patients to find out if these characteristics are intercorrelated. A significant correlation between MAO activity and sensitivity to PGI2 was found.

Original languageEnglish
Pages (from-to)691-695
Number of pages5
JournalPolish journal of pharmacology and pharmacy
Volume40
Issue number6
Publication statusPublished - jan. 1 1988

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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