Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis

I. Altorjay, Zsuzsanna Vitalis, Istvan Tornai, K. Palatka, Sandor Kacska, Gyula Farkas, M. Udvardy, J. Hársfalvi, Tamas Dinya, Peter Orosz, Bela Lombay, G. Pár, A. Pár, Timea Csak, J. Osztovits, F. Szalay, Antal Csepregi, P. Lakatos, M. Papp

Research output: Article

15 Citations (Scopus)

Abstract

Background & Aims: Mannose-binding lectin (MBL) is a serum lectin synthesized by the liver and involved in innate host defense. MBL deficiency increases the risk of various infectious diseases mostly in immune-deficient conditions. Bacterial infections are a significant cause of morbidity and mortality in liver cirrhosis due to the relative immuncompromised state. Methods: Sera of 929 patients with various chronic liver diseases [autoimmune liver diseases (ALD), 406; viral hepatitis C (HCV), 185; and liver cirrhosis (LC) with various etiologies, 338] and 296 healthy controls (HC) were assayed for MBL concentration. Furthermore, a follow-up, observational study was conducted to assess MBL level as a risk factor for clinically significant bacterial infections in cirrhotic patients. Results: MBL level and the prevalence of absolute MBL deficiency (

Original languageEnglish
Pages (from-to)484-491
Number of pages8
JournalJournal of Hepatology
Volume53
Issue number3
DOIs
Publication statusPublished - szept. 2010

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Mannose-Binding Lectin
Bacterial Infections
Liver Cirrhosis
Liver Diseases
Hepatitis C
Serum
Lectins
Autoimmune Diseases
Observational Studies
Communicable Diseases
Chronic Disease
Morbidity
Mortality
Mannose-Binding Protein Deficiency
Liver

ASJC Scopus subject areas

  • Hepatology

Cite this

Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis. / Altorjay, I.; Vitalis, Zsuzsanna; Tornai, Istvan; Palatka, K.; Kacska, Sandor; Farkas, Gyula; Udvardy, M.; Hársfalvi, J.; Dinya, Tamas; Orosz, Peter; Lombay, Bela; Pár, G.; Pár, A.; Csak, Timea; Osztovits, J.; Szalay, F.; Csepregi, Antal; Lakatos, P.; Papp, M.

In: Journal of Hepatology, Vol. 53, No. 3, 09.2010, p. 484-491.

Research output: Article

Altorjay, I. ; Vitalis, Zsuzsanna ; Tornai, Istvan ; Palatka, K. ; Kacska, Sandor ; Farkas, Gyula ; Udvardy, M. ; Hársfalvi, J. ; Dinya, Tamas ; Orosz, Peter ; Lombay, Bela ; Pár, G. ; Pár, A. ; Csak, Timea ; Osztovits, J. ; Szalay, F. ; Csepregi, Antal ; Lakatos, P. ; Papp, M. / Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis. In: Journal of Hepatology. 2010 ; Vol. 53, No. 3. pp. 484-491.
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AU - Altorjay, I.

AU - Vitalis, Zsuzsanna

AU - Tornai, Istvan

AU - Palatka, K.

AU - Kacska, Sandor

AU - Farkas, Gyula

AU - Udvardy, M.

AU - Hársfalvi, J.

AU - Dinya, Tamas

AU - Orosz, Peter

AU - Lombay, Bela

AU - Pár, G.

AU - Pár, A.

AU - Csak, Timea

AU - Osztovits, J.

AU - Szalay, F.

AU - Csepregi, Antal

AU - Lakatos, P.

AU - Papp, M.

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KW - Chronic liver diseases

KW - Liver cirrhosis

KW - Mannose-binding lectin

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