Lymphoid metastasis of rat My2/De leukemia

G. Trencsenyi, G. Nagy, B. Kahlik, E. Nemeth, P. Kertai, A. Kiss, G. Banfalvi

Research output: Article

3 Citations (Scopus)

Abstract

By grafting spontaneous leukemia tumor cells, the myeloid My2/De leukemia rat model was established. Death was caused by impaired functions of heavily infiltrated organs. In vitro culturing of tumor cells, blood and bone marrow counts and cytochemic reactions indicated the leukemic the origin resembling human myeoloblastic leukemia. Metastatic spread was followed after i.v. and i.p. injection, and by implantation of leukemia cells under the renal capsule of rats. Primary tumor and metastasis formation was visualized by 18FDG or 11C-methionine administration and MiniPET. The accumulation of radiotracers was measured in different organs and expressed as Differential Absorption Ratios (DARs). Subrenal implantation of My2/De cells resulted in their appearance in other abdominal organs and in parathymic lymph nodes. The release of tumor cells from the primary kidney to the peritoneum was mimicked by the i.p. administration of ink particles. Ink particles deposited in the abdominal organs and in the thoracal lymph nodes, preferentially in parathymic lymph nodes, confirming the notion of lymphatic spread of metastasis.

Original languageEnglish
Pages (from-to)586-593
Number of pages8
JournalLeukemia Research
Volume38
Issue number5
DOIs
Publication statusPublished - máj. 2014

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Trencsenyi, G., Nagy, G., Kahlik, B., Nemeth, E., Kertai, P., Kiss, A., & Banfalvi, G. (2014). Lymphoid metastasis of rat My2/De leukemia. Leukemia Research, 38(5), 586-593. https://doi.org/10.1016/j.leukres.2014.02.006